[关键词]
[摘要]
目的 探讨健脾生血颗粒治疗儿童缺铁性贫血的临床疗效。方法 选取2014年5月-2019年7月河北北方学院附属第一医院门诊收治的缺铁性贫血患儿106例为研究对象,随机将患儿分为观察组和对照组,每组各53例。对照组患儿口服琥珀酸亚铁片,1片/次,2次/d。观察组口服健脾生血颗粒,0.75 g/kg,每天分3次于饭后服用。两组患者均连续服用4周。观察两组患儿的临床疗效,比较两组血清学指标、生长发育指标和不良反应发生率。结果 治疗后,观察组总有效率为90.57%,明显高于对照组的75.47%,两组间比较差异显著(P<0.05)。治疗后,两组血红蛋白(Hb)、血清铁蛋白(SF)、平均红细胞体积(MCV)、平均红细胞血红蛋白(MCH)水平显著升高(P<0.05),且观察组患者的Hb、SF、MCV、MCH水平均高于对照组(P<0.05)。治疗后,两组患儿智力发育指数(MDI)、精神运动发育指数(PDI)、精神运动发育商(DQ)评分均显著升高(P<0.05);且观察组患儿的贝利量表评分均高于对照组(P<0.05)。治疗期间,两组不良反应发生率比较差异无统计学意义。结论 健脾生血颗粒治疗患儿缺铁性贫血的疗效较好,能够升高患儿机体Hb、SF、MCV、MCH等指标水平,改善患儿的发育状态,且治疗安全性良好,值得临床推荐。
[Key word]
[Abstract]
Objective To study the clinical effect of Jianpi Shengxue Granules in treatment of iron deficiency anemia in children. Methods Children (106 cases) with iron deficiency anemia in the First Affiliated Hospital of Hebei North University from May 2014 to July 2019 were randomly divided into observation group and control group, 53 cases in each group. Children in the control group were po administered with Ferrous Succinate Tablets, 1 tablet/time, twice daily. Children in the observation group were po administered with Jianpi Shengxue Granules, 0.75 g/kg, taken it three times after meals. Patients in two groups were treated continuously for 4 weeks. The clinical efficacy in two groups was observed, the serological indexes, growth and development indexes, and the incidence of adverse reactions were compared between two groups. Results After treatment, the total effective rate in the observation group was 90.57%, which was higher than 75.47% in the control group (P<0.05). After treatment, the levels of Hb, SF, MCV, and MCH in two groups were significantly increased (P<0.05), and the Hb, SF, MCV, and MCH levels in the observation group were higher than those in the control group (P<0.05). After treatment, the scores of MDI, PDI, and DQ in two groups were significantly increased (P<0.05), and the Bailey scale in the observation group were higher than those in the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between two groups during treatment. Conclusion The therapeutic effect of Jianpi Shengxue Granules in treatment of children with iron deficiency anemia is good, which can increase the levels of Hb, SF, MCV, and MCH of children, and improve the development of children, the treatment safety is good, it is worthy of clinical recommendation.
[中图分类号]
R973
[基金项目]