[关键词]
[摘要]
目的 观察荜铃胃痛颗粒联合莫沙必利治疗老年功能性消化不良餐后不适综合征患者的临床疗效。方法 选取2017年4月-2019年10月在皖南医学院第二附属医院就诊的功能性消化不良餐后不适综合征患者106例,按随机数字表法分为组对照和观察组,每组各53例。对照组患者于餐前30 min口服枸橼酸莫沙必利片,5 mg/次,3次/d。观察组在对照组治疗基础上给予荜铃胃痛颗粒,餐前30 min开水冲服,5 g/次,3次/d。两组连续治疗1周。比较两组餐后不适综合征临床症状评分、临床疗效、血清胃泌素(G-17)、胃蛋白酶原(PG)I、PGII水平和不良反应情况。结果 治疗后,两组患者治疗后餐后饱胀不适、上腹胀、早饱、嗳气、胃纳减少评分明显减少(P<0.01);治疗后,观察组患者的餐后饱胀不适、上腹胀、早饱、嗳气、胃纳减少评分显著低于对照组(P<0.01)。治疗后,观察组总有效率为94.34%,对照组总有效率为77.36%,两组比较差异有统计学意义(P<0.05)。两组患者治疗后血清G-17水平明显减少,血清PGI、PGII水平显著增加(P<0.01);治疗后,观察组患者的血清G-17水平显著低于对照组,PGI、PGII明显高于对照组(P<0.01)。两组均无严重不良反应。结论 荜铃胃痛颗粒联合莫沙必利可有效改善老年功能性消化不良餐后不适综合征患者的症状体征和胃排空功能,提高临床疗效,且安全性较好。
[Key word]
[Abstract]
Objective To observe the efficacy of Biling Weitong Granules combined with mosapride in treatment of elderly patients with postprandial distress syndrome of functional dyspepsia. Methods A total of 106 patients with postprandial distress syndrome of functional dyspepsia in the Second Affiliated Hospital of Wannan Medical College from April 2017 to October 2019 were selected and divided into control group and observation group according to the random number table method, with 53 cases in each group. Patients in the control group were po administered with Mosapride Citrate Tablets 30 min before meals, 5 mg/time, three times daily. Patients in the observation group were po administered with Biling Weitong Granules on the basis of control group, which were taken by boiling water 30 min before the meals, 5 g/time, three times daily. Patients in two groups were treated for 1 week. The clinical symptom scores, clinical efficacy, serum G-17, PG I, PG II levels, and adverse reactions in two groups were compared. Results After treatment, the scores of postprandial satiety and discomfort, upper abdominal distension, early satiety, belching, and gastric absorption reduction in two groups were significantly decreased (P<0.01). After treatment, the score of postprandial satiety and discomfort, upper abdominal distension, early satiety, belching, and gastric absorption reduction in the observation group was significantly lower than those in the control group (P<0.01). After treatment, the total effective rate was 94.34% in the observation group, and 77.36% in the control group, and the difference between two groups was statistically significant (P<0.05). After treatment, the serum levels of G-17 in two groups were significantly decreased, but the PG I and PG II levels were increased (P<0.01), and the level of G-17 in the observation group was significantly lower than those in the control group, the levels of PG I and PG II were significantly higher than those in the control group (P<0.01). There were no serious adverse reactions in two groups. Conclusion BilingWeitongGranulescombinedwithmosapridecaneffectivelyimprovethesymptomsandsigns,gastricemptyingfunction of elderly patients with postprandial distress syndrome of functional dyspepsia, and improve the clinical efficacy, with good safety.
[中图分类号]
R975
[基金项目]
国家自然科学基金青年科学基金项目(81800445)