目的 观察注射用丹参多酚酸治疗前循环急性脑梗死对患者血清基质金属蛋白酶-9（MMP-9）水平的影响。方法选取2017年1月—2018年12月郑州市第一人民医院治疗的112例前循环急性脑梗死患者，按照1∶1的比例随机分配到对照组和观察组。对照组给予缺血性脑血管病基础治疗，观察组在对照组治疗的基础上静脉滴注注射用丹参多酚酸，将0.13 g注射用丹参多酚酸溶于250 mL 0.9%氯化钠注射液中，1次/d。两组均以14 d为1个疗程。比较两组患者治疗前、治疗7 d及治疗14 d后血清MMP-9水平变化情况。结果 治疗7、14 d后，两组患者血清MMP-9水平均显著低于治疗前，同组治疗前后比较差异具有统计学意义（P<0.05）；且观察组患者血清MMP-9水平显著低于对照组，两组比较差异有统计学意义（P<0.05）。观察组患者治疗14 d后，血清MMP-9水平较治疗7 d后有显著降低（P<0.05）。结论 注射用丹参多酚酸治疗前循环急性脑梗死患者能够持久、有效的降低患者血清MMP-9水平，疗效确切。

Objective To observe the efficacy of Salvianolic Acids for injection on MMP-9 levels of anterior circulation acute cerebral infarction patients. Methods A total of 112 patients with anterior circulation acute cerebral infarction in the First People Hospital of Zhengzhou City from January 2017 to December 2018 were randomly divided into control group and observation groups at the ratio of 1: 1. Patients in the control group were received basic treatment, and patients in the observation group were iv administered with Salvianolic Acids for injection on the basis of control group, 0.13 g were added into 0.9% sodium chloride injection 250 mL, once daily. Patients in two groups were treated for 14 d. The serum levels of MMP-9 of patients in two groups were detected at the beginning, 7 and 14 d after treatment, respectively. Results Compared to before treatment, the serum MMP-9 level were significantly decreased after treatment of 7 and 14 d after treatment, the difference was statistically significant (P < 0.05). Comparing with the control group, the serum MMP-9 level in the observation group were decreased significantly at not only the 7th day but also the 14th day after admission, which was statistically significant (P < 0.05). Conclusion Salvianolic Acids for Injection can reduce the serum mmp-9 level of patients with anterior circulation acute cerebral infarction for a long time, and the effect is definite.

R969.4