[关键词]
[摘要]
目的 探讨注射用丹参多酚酸对老年脑梗死患者炎性因子和预后的影响。方法 选取2017年10月—2018年4月在许昌市中心医院神经科住院的302例脑梗死患者作为研究对象,根据随机数字表法分为观察组(149例)和对照组(153例)。对照组患者给予常规脑梗死二级预防治疗,观察组患者在对照组基础上静脉滴注注射用丹参多酚酸,100 mg用0.9%氯化钠注射液250 mL稀释,1次/d,连续用药14 d。治疗后,比较两组治疗前后血清白细胞介素-6(IL-6)、超敏C反应蛋白(hs-CRP)水平,采用改良Rankin量表(MRs)评估两组预后情况。随访6个月,比较两组不良事件发生率及药品不良反应发生情况。结果 治疗后,两组患者IL-6、hs-CRP水平均显著低于治疗前(P<0.05),且观察组IL-6、hs-CRP水平显著低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组预后良好率为77.1%,显著高于对照组的62.4%,差异有统计学意义(P<0.05)。两组不良事件总发生率及药品不良反应总发生率差异无统计学意义。结论 注射用丹参多酚酸能够显著降低老年脑梗死患者的炎性因子水平,且能显著改善患者预后,具有一定的临床推广应用价值。
[Key word]
[Abstract]
Objective To investigate the effect of Salvianolate for injection on inflammatory factors and prognosis in elderly patients with cerebral infarction. Methods Elderly patients (302 cases) with cerebral infarction in the Xuchang Central Hospital from October 2017 to April 2018 were randomly divided into observation group (149 case ) and control group (153 cases). Patients in the control group were given secondary conventional prevention and treatment of cerebral infarction, while patients in the observation group were iv administered with Salvianolate for injection on the basis of control group, 100 mg diluted with 250 mL 0.9% sodium chloride injection, once daily, and patients were treated for 14 d. After treatment, the serum levels of IL-6 and hs-CRP were compared between two groups before and after treatment. The prognosis of two groups was evaluated by modified Rankin scale (MRs). Follow-up for 6 months, the incidence of adverse events and adverse drug reactions were compared between two groups. Results The levels of IL-6 and hs-CRP in two groups after treatment were significantly lower than those before treatment (P < 0.05), and the levels of IL-6 and hs-CRP in the observation group were significantly lower than those in the control group, the difference was statistically significant (P < 0.05). The good prognosis rate in the observation group was 77.1%, which was significantly higher than 62.4% in the control group, the difference was statistically significant (P < 0.05). The total incidence of adverse events and adverse drug reactions in two groups were no significant difference. Conclusion Salvianolate for injection can significantly reduce the level of inflammatory factors in elderly patients with cerebral infarction, and can significantly improve the prognosis of patients, it has certain clinical promotion and application value.
[中图分类号]
R969.4
[基金项目]
河南省医学科技攻关项目(201602372)