[关键词]
[摘要]
目的 观察注射用丹参多酚酸对卒中后认知障碍患者血清细胞间黏附分子-1(ICAM-1)、血管细胞粘附分子-1(VCAM-1)、β-淀粉样蛋白(Aβ)-42水平和蒙特利尔认知评估量表(MoCA)评分的影响。方法 选取2018年1月—2019年4月河南大学第一附属医院住院的102例卒中后认知功能障碍患者作为研究对象。根据随机数字表方法,将患者分为对照组和观察组,每组各51例。对照组静脉滴注注射用血塞通,400 mg加入生理盐水250 mL,1次/d;观察组静脉滴注注射用丹参多酚酸,130 mg加入生理盐水250 mL,1次/d。两组患者均治疗2周。比较治疗前后两组患者血清细胞间黏附分子-1(ICAM-1)、血管细胞粘附分子-1(VCAM-1)、β-淀粉样蛋白(Aβ)-42水平和蒙特利尔认知评估量表(MoCA)评分。结果 与治疗前的水平相比,对照组Aβ-42水平显著降低,观察组的ICAM-1、VCAM-1和Aβ-42血清水平大幅下降,同组治疗前后比较差异具有统计学意义(P<0.05);观察组的ICAM-1、VCAM-1血清水平与对照组相比显著下降,两组比较差异具有统计学意义(P<0.05)。治疗后,两组MoCA评分显著升高,同组治疗前后比较差异具有统计学意义(P<0.05);且治疗后观察组MoCA量表评分显著高于对照组,两组比较差异具有统计学意义(P<0.05)。结论 注射用丹参多酚酸对脑卒中后认知功能障碍患者的血清ICAM-1、VCAM-1水平有改善作用,并能减少Aβ-42的生成,提高其认知功能。
[Key word]
[Abstract]
Objective To observe the effect of Salvianolate for injection on serum ICAM-1,VCAM-1, and Aβ-42 levels and MoCA score in patients with post-stroke cognitive impairment. Methods Patients (102 cases) with post-stroke cognitive impairment in the First Affiliated Hospital of Henan University from January 2018 to April 2019 were divided into control group and observation group acccording to random number table method, and each group had 51 cases. Patients in the control group were iv administered with Xuesaitong Injection, 400 mg were added into 250 mL saline, once daily. Patients in the observation group were iv administered with Salvianolate for injection, 130 mg were added into 250 mL saline, once daily. Patients in two groups were treated for 2 weeks. The levels of ICAM-1, VCAM-1, Aβ-42, and MoCA score in two groups before and after treatment were compared. Results Compared with the level of before treatment, Aβ-42 in the control group were decreased significantly, and the serum levels of ICAM-1, VCAM-1 and Aβ-42 in the observation group were decreased significantly, with significant difference before and after treatment in the same group (P < 0.05). The serum levels of ICAM-1 and VCAM-1 in the observation group were decreased significantly compared with those in the control group, and the difference between two groups was significant (P < 0.05). After treatment, the MoCA score in two groups were significantly increased, and the difference was statistically significant in the same group (P < 0.05). And the MoCA score in the observation group was significantly higher than that in the control group, with significant difference between two groups (P < 0.05). Conclusion Salvianolate for injection can improve the serum levels of ICAM-1 and VCAM-1 in patients with post-stroke cognitive impairment, reduce the generation ofAβ-42, and improve its cognitive function.
[中图分类号]
R969.4
[基金项目]
河南省医学科技攻关项目(2017T02048)