目的 探讨注射用丹参多酚酸联合阿司匹林对脑梗死患者氧化产物和炎症因子的影响。方法 选取2018年6月—2019年6月于黑龙江中医药大学附属第一医院治疗的脑梗死患者68例作为研究对象，并按随机数字表法将其分成观察组（34例）和对照组（34例）。对照组口服阿司匹林肠溶片，100 mg/次，1次/d，并予以对症治疗，观察组在对照组治疗的基础上静脉滴注注射用丹参多酚酸，100 mg/次，临用前以适量0.9%氯化钠注射液将药物溶解，再用250 mL 0.9%氯化钠注射液将药物稀释，1次/d。两组治疗周期为14 d。观察对比两组患者血清丙二醛（MDA）、晚期氧化蛋白产物（AOPP）、超氧化物歧化酶（SOD）、谷胱甘肽（GSH）、C反应蛋白（CRP）、降钙素原（PCT）表达水平及美国国立卫生研究院卒中量表（NIHSS）评分指标。结果 治疗后，两组患者血清MDA、AOPP水平均明显降低（P<0.05）；观察组MDA、AOPP水平显著低于对照组（P<0.05）。治疗后，两组血清SOD、GSH水平均明显升高（P<0.05），且观察组SOD、GSH水平显著高于对照组（P<0.05）。治疗后，两组血清CRP、PCT水平及NIHSS评分均明显降低（P<0.05），且观察组CRP、PCT表达水平及NIHSS评分均显著低于对照组（P<0.05）。结论 注射用丹参多酚酸联合阿司匹林能够降低脑梗死患者血清氧化产物，增高抗氧化产物，降低炎性因子释放，并能加快神经功能的恢复。

Objective To investigate the effects of Salvianolic Acids for Injection combined with aspirin on oxidative products and inflammatory factors in patients with cerebral infarction. Methods Patients (68 cases) with cerebral infarction in the First Affiliated Hospital of Heilongjiang University of Chinese Medicine from June 2018 to June 2019 were divided into observation group (34 cases) and control group (34 cases). Patients in the control group were po administered with Aspirin Enteric-coated Tablets, 100 mg/ time, once daily, and received symptomatic treatment. Patients in the observation group were iv administered with Salvianolic Acids for injection on the basis of treatment of the control group at 100 mg/time. Before use, the drug was dissolved with an appropriate amount of 0.9% sodium chloride injection, and then diluted with 250 mL 0.9% sodium chloride injection for once daily. The two groups were treated for 14 d. After 14 d of treatment, the serum levels of MDA, AOPP, SOD, GSH, CRP, PCT and NIHSS scores in two groups were observed and compared. Results After treatment, the serum levels of MDA and AOPP in two groups were significantly decreased (P < 0.05). After treatment, the serum levels of MDA and AOPP in the observation group were significantly lower than those in the control group (P < 0.05). After treatment, the serum SOD and GSH levels in two groups were significantly increased (P < 0.05). And the levels of SOD and GSH in the observation group were significantly higher than those in the control group (P < 0.05). After treatment, the serum levels of CRP, PCT and NIHSS score in two groups were significantly decreased (P < 0.05). And the levels of CRP, PCT and NIHSS score in the observation group were significantly lower than those in the control group (P < 0.05). Conclusion SalvianolicAcids for injection combined with aspirin can reduce serum oxidation products in patients with cerebral infarction, increase antioxidant products, reduce inflammatory factor release, and accelerate the recovery of nerve function.

R969.4