苦参碱能剂量相关地抑制人肝癌HepG2细胞增殖、迁移、侵袭和血管内皮生长因子表达，能诱导HepG2细胞凋亡和分化。苦参碱是HepG2细胞的自噬早期诱导剂，更是自噬晚期抑制剂，其通过诱导线粒体应缴、内质网应激和抑制ERK信号通路、人宫颈癌基因-1、Apollon基因表达和端粒酶活性，产生抗HepG2细胞的作用。

Matrine inhibits proliferation, migration, invasion, and expression of vascular endothelial growth factor, and induces apoptosis and differentiation in association with dosage on human hepatoma HepG2 cells. Matrine is a inducer of early stage of autophagy, and is more a inhibitor of late stage of autophagy. Matrine has the effect against HepG2 cells by induction of mitochondria stress and endoplasmic reticulum stress, and inhibition of ERK pathway, expression of human cervical cancer oncogene-1 and Apollon gene, and telomerase activity.

R288.1