[关键词]
[摘要]
酸浆苦素A是酸浆属植物酸浆的主要活性成分之一,具有良好的抗肿瘤作用和抗炎作用。药理研究表明酸浆苦素A可以显著抑制脂多糖诱导巨噬细胞中一氧化氮的产生,从而发挥抗炎功效,作用机制可能与其修饰IκB激酶β、抑制NF-κB活性相关;还显著抑制黑色素瘤、非小细胞肺癌、前列腺癌和肝癌肿瘤细胞的成长,其抗肿瘤作用机制可能与诱导肿瘤细胞凋亡、抑制JAK/STAT 3信号传导相关。对酸浆苦素A的药理作用进行综述,旨在为进一步开发与应用提供文献依据。
[Key word]
[Abstract]
Physalin A is one of the main active constituents of Physalis alkekengi L.var. franchetii (Mast.) Makino which possesses excellent anti-tumor and anti-inflammatory activities. Pharmacological researches showed that physalin A exerted anti-inflammatory effects via significantly inhibiting the production of nitric oxide in macrophages induced by lipopolysaccharide and its mechanism of action may be related to its inhibition of NF-κB activity by modifying IκB kinase β. Additionally, physalin A obviously inhibits the growth of melanoma, non-small cell lung cancer, prostate cancer, and liver cancer tumor cells and its anti-tumor mechanism may be related to its ability to induce tumor cell apoptosis and inhibit JAK/STAT 3 signaling. This article reviews the pharmacological effects of physalin A to provide literature references for the further development and application of physalin A.
[中图分类号]
R285.5
[基金项目]
国家自然科学基金资助项目(81873079);国家重大新药创制专项(2017ZX09301012-001)