目的 探讨丹田降脂丸联合依折麦布片治疗高脂血症的临床效果。方法 选取2017年2月—2019年2月辽宁省人民医院收治的92例高脂血症患者，运用随机数字表法将其随机分成观察组（n=46）与对照组（n=46）。对照组口服依折麦布片，10 mg/次，1次/d；观察组在对照组基础上口服丹田降脂丸，1 g/次，2次/d。两组均治疗8周。对比两组临床疗效，同时比较两组患者治疗前后的三酰甘油（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、全血高切黏度（HBV）、全血低切黏度（LBV）、红细胞变形指数（RDI）、血小板最大聚集率（MAR）值，血浆纤维蛋白原（FIB）、血清C反应蛋白（CRP）、血清肿瘤坏死因子-α（TNF-α）及瘦素（LEP）水平。结果 治疗后，观察组总有效率为95.7%，显著高于对照组的82.6%（P<0.05）。两组治疗后血清TG、TC、LDL-C水平均显著低于治疗前，而HDL-C水平均显著升高（P<0.05）；且治疗后，观察组血脂水平的改善效果显著优于对照组（P<0.05）。与治疗前相比，两组治疗后HBV、LBV、MAR值均显著降低，RDI值则显著增加（P<0.05）；且观察组血液流变学参数及MAR值的改善效果更显著（P<0.05）。两组治疗后血浆FIB水平及血清CRP、TNF-α、LEP水平较治疗前均显著下降（P<0.05）；治疗后，观察组血浆FIB水平及血清CRP、TNF-α、LEP水平较对照组显著更低（P<0.05）。结论 应用丹田降脂丸联合依折麦布片治疗高脂血症的整体疗效切实，有助于纠正血脂异常，改善血液高凝状态，抑制血小板聚集，防止血栓形成，减轻机体炎性损伤，改善LEP抵抗，且病人耐受性好，值得临床推广应用。

Objective To investigate the clinical effect of Dantian Jiangzhi Pills combined with Ezetimibe Tablets in treatment of hyperlipidemia. Methods Patients (92 cases) with hyperlipidemia admitted to Liaoning Provincial People's Hospital from February 2017 to February 2019 were randomly divided into observation group (n=46) and control group (n=46) by random number table method. The control group was treated with Ezetimibe Tablets 10 mg/time, once daily. While the observation group was treated with Dantian Jiangzhi Pills on the basis of control group, 1 g/time, twice daily. All patients were treated for 8 weeks. The clinical effects in two groups were compared, and the levels of TG, TC, HDL-C, LDL-C, HBV, LBV, RDI, MAR, FIB, CRP, TNF-α, and LEP in two groups before and after treatment were compared. Results After treatment, the total effective rate of the observation group was 95.7%, which was significantly higher than 82.6% of the control group (P<0.05). After treatment, the serum TG, TC, LDL-C levels in two groups were significantly lower than those before treatment, while HDL-C levels were significantly increased (P<0.05). After treatment, the improvement effect of blood lipid levels in the observation group was significantly better than those in the control group (P<0.05). Compared with before treatment, HBV, LBV, and MAR values in two groups were significantly decreased, but RDI values were significantly increased (P<0.05). In addition, the improvement effect of hemorheology parameters and MAR value in the observation group was more significant (P<0.05). After treatment, the levels of plasma FIB, and serum CRP, TNF-α and LEP in two groups were decreased significantly (P<0.05). After treatment, the plasma FIB level, CRP, TNF-α and LEP levels in the observation group were significantly lower than those in the control group (P<0.05). Conclusion Dantian Jiangzhi Pills combined with Ezetimibe Tablets in treatment of hyperlipidemia has a practical overall effect, which is helpful to correct the abnormal blood lipid, improve the blood hypercoagulable state, inhibit platelet aggregation, prevent thrombosis, reduce the inflammatory damage of the body, improve the LEP resistance, and the patient has a good tolerance, which is worthy of clinical application.

R973