目的 探讨百蕊颗粒联合头孢克洛颗粒治疗小儿急性支气管炎的临床疗效。方法 选取2017年5月—2019年5月在海南医学院第一附属医院进行治疗的86例急性支气管炎患儿为研究对象，根据用药的差别将患儿分为观察组（43例）和对照组（43例）。对照组给予头孢克洛颗粒，20～40 mg/（kg·d），分3次给予，1日总量不超过1 g；观察组在对照组基础上口服百蕊颗粒，5 g/次，3次/d。两组患儿均经7 d治疗后进行效果对比。结果 经治疗，对照组总有效率为81.40%，显著低于观察组的97.67%，两组比较差异具有统计学意义（P<0.05）。治疗后，观察组咳嗽咳痰、喘息气急、发热及肺部啰音消失时间均短于对照组，两组比较差异具有统计学意义（P<0.05）。经治疗，两组血清超敏C反应蛋白（hs-CRP）、降钙素原（PCT）、肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）、可溶性髓系细胞触发受体-1（sTREM-1）水平均显著下降，同组治疗前后比较差异具有统计学意义（P<0.05）；且观察组血清学指标显著低于对照组，两组比较差异具有统计学意义（P<0.05）。结论 百蕊颗粒联合头孢克洛颗粒治疗小儿急性支气管炎可显著促进患儿症状改善，降低炎症细胞因子水平，具有良好的临床应用价值。

Objective To explore the clinical effect of Bairui Granules combined with Cefaclor Granules in treatment of acute bronchitis in children. Methods Children (86 cases) with acute bronchitis treated in The First Affiliated Hospital of Hainan Medical University from May 2017 to May 2019 were divided into observation group (43 cases) and control group (43 cases) according to the difference of medication. The control group was given Cefaclor Granules, 20 — 40 mg/(kg· d) for three times, and the total amount of Cefaclor Granules per day was no more than 1 g. Children in the observation group were po administered Bairui Granules on the basis of the control group, 5 g/time, three times daily. The effect of 7 d treatment was compared between the two groups. The therapeutic effect in two groups was compared after treatment for 7 d. Results After treatment, the effective rate in the control group was 81.40%, which was significantly lower than 97.67% in the observation group, and there were differences between two groups (P < 0.05). After treatment, the disappearance time of symptoms such as cough and sputum, shortness of breath, fever, and lung rale in the observation group were significantly better than those in the control group, and there were differences between two groups (P < 0.05). After treatment, the serum levels of hs-CRP, PCT, TNF- α, IL-6, and sTREM-1 in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). After treatment, serological indexes in the observation group was significantly lower than those in the control group, with significant difference between two groups (P < 0.05). Conclusion Bairui Granules combined with Cefaclor Granules in treatment of children with acute bronchitis can effectively improve the clinical symptoms, and reduce the inflammatory cytokines levels, which has good clinical application value.

R974

海南省卫生计生行业科研项目（16A200012）