Combined with the revision of the current traditional Chinese medicine (TCM) registration classification, this paper has considered the new TCM application materials and the technical requirements of new natural medicines. Unlike chemical drugs, most of the new TCM compound preparations have experience for people to evaluate, considering how to apply different evidence classifications of human experience, and reduce the application materials. Medical institution TCM preparations have high clinical evidence of clinical application experience. It is recommended to investigate the situation of medical institution TCM preparations, promote the conversion of medical institution TCM preparations into new TCM, and provide reference for the establishment of a review system that conforms to the characteristics of TCM. In addition, based on the complex mixture of natural medicines and TCM, it is recommended that the pharmacy and pharmacological toxicological requirements of new natural medicines should be consistent with the new TCM. The clinical requirements of new natural medicines refer to the clinical technical requirements of new chemical drugs.