目的 探讨重组人脑利钠肽冻干粉剂联合猪肺磷脂注射液治疗窒息儿早产儿对右室Tei指数的影响。方法 采用回顾性、便利抽样研究方法，选取2015年8月—2018年1月在郑州市第七人民医院诊治的窒息儿早产儿120例作为研究对象，根据治疗方法的不同分为观察组60例与对照组60例。对照组给予猪肺磷脂注射液200 mg/kg气管滴注结合呼吸支持治疗，观察组在对照组治疗的基础上给予重组人脑利钠肽冻干粉剂辅助治疗，负荷剂量0.5 μg/kg，维持剂量速率为0.005～0.01μg/（kg·min），治疗48 h。记录两组患儿机械通气时间、住院天数、BNP水平、左室与右室Tei指数变化情况及患儿治疗后2、24 h的肺泡内正压参数。结果 观察组的机械通气时间与住院天数分别为（2.74±0.87）d和（22.19±3.29）d，都显著短于对照组的（5.29±1.20）d和（27.82±3.11）d（P<0.05）。治疗后，两组的BNP值都显著低于治疗前（P<0.05），治疗后观察组的BNP值与对照组相比无显著差异。两组治疗后的左室与右室的Tei指数都显著高于治疗前（P<0.05），治疗后观察组的Tei指数也显著高于对照组（P<0.05）。观察组治疗后2、24 h的肺泡内正压参数都显著高于对照组（P<0.05）。结论 重组人脑利钠肽冻干粉剂联合猪肺磷脂注射液治疗窒息儿早产儿能改善患儿的右室Tei指数，调节体内BNP水平，改善肺泡内正压参数，从而促进患儿康复。

Objective To investigate the effects of recombinant human brain natriuretic peptide freeze-dried powder combined with Poractant Alfa Injection on right ventricular Tei index in asphyxiated premature infants. Methods Used a retrospective, convenience sampling method, 120 cases of asphyxiated premature infants in Zhengzhou NO.7 People's Hospital from August 2015 to January 2018 were selected as the research object, children were divided into the observation (60 cases) and control (60 cases) groups according to the different treatment methods. Children in the control group were received 200 mg/kg intratracheal infusion of Poractant Alfa Injection combined with respiratory support treatment. Children in the observation group was given recombinant human brain natriuretic peptide freeze-dried powde adjuvant therapy based on the control group, the load dose was 0.5μg/kg, the maintenance dose rate was 0.005-0.01μg/(kg·min), and the treatment lasted 48 h. Mechanical ventilation time, hospitalization days, BNP level, changes of left and right ventricular Tei index, and alveolar positive pressure parameters at 2 and 24 h after treatment were recorded. Results After treatment, the duration of mechanical ventilation and hospitalization days in the observation group were (2.74 ±0.87) d and (22.19 ±3.29) d, respectively, which were significantly less than those in the control group of (5.29 ±1.20) d and (27.82 ±3.11) d (P<0.05). After treatment, the BNP value in two groups were significantly lower than that of the control group (P<0.05), and the BNP value in the observation group was not significantly different compared to the control group after treatment. After treatment, Tei index of left ventricle and right ventricle in two groups were significantly higher than that before treatment (P<0.05), and the Tei index in the observation group were also higher than that of the control group (P<0.05). The positive pressure in the alveolar of 2 and 24 h after treatment in the observation group were significantly higher than that in the control group (P<0.05). Conclusion The recombinant human brain natriuretic peptide freeze-dried powder combined with Poractant Alfa Injection can improve the right ventricular Tei index, and regulate the level of BNP in vivo, and improve the positive parameters of alveolar pressure in asphyxiated premature infants, so as to promote the rehabilitation of children.