[关键词]
[摘要]
目的 考察新型细菌群体抑制剂RNAIII抑制肽衍生物RIP1183对中枢神经系统、心血管系统和呼吸系统的影响。方法 将ICR种小鼠48只,随机分为对照组和RIP1183低、中、高剂量组(4、12、36 mg/kg),观察iv RIP1183后,对小鼠自主活动次数、协调运动能力和阈下巴比妥钠协同作用的影响。将比格犬随机分组同前,按体表面积换算成相应剂量,观察股iv RIP1183后,对各组犬心血管系统和呼吸系统的影响。结果 与对照组相比,RIP1183对小鼠自主活动、协调运动能力和阈下巴比妥钠协同作用无影响,对比格犬心电图、心率、心律及呼吸频率和幅度、血压无明显影响。结论 RIP1183对中枢神经系统、呼吸系统和心血管系统均无明显影响。研究结果可为RIP1183临床试验研究提供参考。
[Key word]
[Abstract]
Objective To investigate the effects of RIP1183, a novel bacterial population inhibitor RNA III inhibitory peptide derivative, on the central nervous system, cardiovascular system and respiratory system. Methods A total of 48 ICR mice were randomly divided into control group, RIP high, medium, and low dose groups (4, 12 and 36 mg/kg). The effects of iv RIP1183 on the number of spontaneous activities, balance ability, and the synergistic effect of subthreshold sodium barbiturate in mice were observed. The Beagle dogs were randomly divided into the same group and converted into corresponding doses according to body surface area. The effects of iv RIP1183 on cardiovascular and respiratory system were observed. Results Compared with control group, RIP1183 had no effect on mice's autonomic activity, coordinated motor ability, and subthreshold barbiturate synergistic effect. And had no significant effect on ECG, heart rate, rhythm, respiratory rate and amplitude, and the blood pressure of Beagle dogs. Conclusion URIP1183 had no significant effect on the central nervous system, respiratory system and cardiovascular system. The results of the studies can provide references and important guiding significances for the clinical trial of RIP1183.
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[基金项目]
陕西省科技厅自然科学基础研究计划项目(2018JQ8028);陕西省呼吸病预防与诊治工程研究中心开放基金(2017HXKF06);西安医学院博士科研启动基金(2016DOC27);国家科技重大专项-重大新药创制项目(2013ZX09J13108-01B)