随着生物技术的发展，在过去的几十年里越来越多细菌性联合疫苗被批准上市，不仅提高了疫苗覆盖率和接种率，而且减少疫苗管理上的各种成本，同时也减少了由于多次免疫接种给接种者所带来的痛苦。就当前细菌性联合疫苗发展现状以及面临的挑战进行综述，希望对国内细菌性联合疫苗的研发及免疫策略的优化提供一定参考。

With the development of biotechnology, more and more bacterial combination vaccines have been licensed in the past few decades. These vaccines not only improve the coverage and immunization rates of vaccine, but also reduce various costs in vaccine management. Furthermore, the pain caused by multiple immunizations to subjects is also reduced. This article reviews the current status and challenges of bacterial combination vaccines, which will provide the reference for the development of domestic bacterial vaccines and optimization of immunization strategies.

国家重大研发计划（2018YFC1603900）；国家自然科学基金项目（81401249）