目的 探讨门冬胰岛素联合地特胰岛素对新诊断2型糖尿病（T2DM）患者血糖和胰岛β细胞功能的影响。方法 选取西电集团医院2017年1月-2018年12月收治的100例新诊断T2DM患者为研究对象，按就诊顺序分为两组，每组50例。对照组采取地特胰岛素皮下注射，观察组采取门冬胰岛素联合地特胰岛素皮下注射。对比两组用药对新诊断T2DM患者血糖和胰岛β细胞功能的影响。结果 两组治疗前空腹血糖（FPG）、餐后2 h血糖（2 h PG）、糖化血红蛋白（HbA1c）对比无统计学差异；经治疗，观察组各项血糖指标均明显下降（P<0.05），下降幅度明显优于对照组（P<0.05）。两组治疗前空腹血清C肽（FC-P）、餐后2 h血清C肽（2 h C-P）对比无统计学差异；经治疗，观察组的FC-P、2 h C-P明显提高（P<0.05），且高于对照组，具有统计学差异（P<0.05）；观察组血糖达标时间明显短于对照组（P<0.05）。两组治疗前胰岛β细胞功能指数（HBCI）对比无统计学差异，治疗后，观察组HBCI明显高于对照组，具有统计学差异（P<0.05）。结论 对于新诊断T2DM患者，采取门冬胰岛素联合地特胰岛素治疗可有效控制血糖，促使胰岛β细胞功能恢复，治疗效果显著，值得临床上进一步推广应用。

Objective To investigate the effects of insulin aspartate combined with insulin detemir on blood glucose and islet β cell function in newly diagnosed T2DM patients. Methods A total of 100 newly diagnosed T2DM patients admitted to Xi'an Xidian Group Hospital from January 2017 to December 2018 were selected as study objects, and were divided into two groups according to the patients' medical order, 50 cases in each group. The control group received subcutaneous injection of insulin detemir, and the observation group received subcutaneous injection of insulin detemir combined with insulin aspart. The effect of blood glucose and island β cell function were compared. Results There was no significant difference in FPG, 2 h PG, and HbA1c between two groups before treatment. After treatment, all blood glucose indexes in two groups were significantly decreased, and the decrease rate in the observation group was significantly better than that in the control group (P<0.05). Serum C-peptide and 2 h C-P were not significantly different. After treatment, FC-P and 2 h C-P in the observation group were significantly higher than those in the control group (P<0.05), and the time of blood glucose attainment in the observation group was significantly shorter than that in the control group (P<0.05). There was no significant difference in HBCI before treatment. After treatment, HBCI in the observation group was significantly higher than that in the control group (P<0.05). Conclusion For newly diagnosed T2DM diabetes mellitus, insulin detemir combined with insulin aspartate can effectively control blood glucose, promote the recovery of pancreatic β cell function, and obtain satisfactory therapeutic effect, which is worthy of further clinical application.