目的 研究苦碟子注射液联合依帕司他对糖尿病周围神经病变的疗效。方法 选择2017年1月-2018年12月喀什地区第二人民医院收治的100例糖尿病周围神经病变患者为研究对象，随机分为两组。对照组口服依帕司他片，50 mg/次，3次/d。观察组在对照组基础上联用苦碟子注射液，将40 mL苦碟子注射液加入250 mL生理盐水中静脉滴注，1次/d。两组均治疗14 d。比较两组患者的临床疗效，同时比较两组治疗前后的胫神经和正中神经的传导速度。结果 治疗后，观察组的有效率为86.00%，明显高于对照组的70.00%，差异有统计学意义（P<0.05）。治疗后，两组胫神经的传导速度明显加快，波幅明显升高，潜伏期明显缩短，同组治疗前后比较差异有统计学意义（P<0.05）；且观察组的胫神经传导速度明显优于对照组，差异有统计学意义（P<0.05）。两组治疗后的正中神经的潜伏期明显缩短，波幅明显升高，传导速度明显加快，同组治疗前后比较差异有统计学意义（P<0.05）；且观察组的正中神经传导速度明显优于对照组，差异有统计学意义（P<0.05）。结论 苦碟子注射液联合依帕司他对糖尿病周围神经病变的疗效较为理想，可明显改善神经传导速度。

Objective To study the effect of Kudiezi Injection combined with epalrestat on diabetic peripheral neuropathy and nerve conduction velocity. Methods Selected 100 cases of patients with diabetic peripheral neuropathy in Kashgar Pregecture Second People's Hospital from January 2017 to December 2018 were divided into two groups randomly. Patients in the control group was given Epalrestat Tablets orally, 50 mg/time, three times daily. While patients in the observation group were iv administered with Kudiezi Injection, 40 mL added into 250 mL normal saline, once daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacies were evaluated, and the conduction velocities of tibial and median nerves were compared between two groups. Results After treatment, the effective rate of the observation group was 86.00%, which was significantly higher than 70.00% in the control group (P<0.05). After treatment, the conduction velocity of tibial nerve in two groups were significantly accelerated, the amplitude were significantly increased, the latency were significantly shortened (P<0.05), and the conduction velocity of tibial nerve in the observation group was significantly better than that in the control group (P<0.05). After treatment, the latency of median nerve in two groups were significantly shortened, the amplitude were significantly increased, the conduction velocity were significantly accelerated (P<0.05), and the conduction velocity of median nerve in the observation group was significantly better than that in the control group (P<0.05). Conclusion Kudiezi Injection combined with epalrestat is effective in treating diabetic peripheral neuropathy, and can significantly improve nerve conduction velocity.

国家自然科学基金-地区科学基金项目（82560112）；喀什地区第二人民医院院内科研项目（KSEY201707）