目的 评价神经节苷脂联用纳洛酮治疗新生儿缺氧缺血性脑病（HIE）的有效性和安全性。方法 计算机检索PubMed、EMBASE、Cochrane图书馆、中国生物医学文献数据库（CBM）、中国学术期刊全文数据库（CNKI）、维普中文期刊全文数据库（VIP）和万方数据库（Wanfang Database），检索时间均从建库至2019年3月，纳入有关神经节苷脂联用纳洛酮治疗HIE的随机对照试验（RCT），采用RevMan 5.3软件进行统计学处理。结果 共纳入15篇RCTs，1 116例患儿。Meta-分析显示：与对照组比较，试验组的临床有效率显著提高（RR=1.25，95% CI=1.18～1.33，P<0.01）、NBNA评分显著改善（MD=4.24，95% CI=3.72～4.76，P<0.01）、意识恢复时间显著减少（MD=-2.13，95% CI=-2.54～-1.71，P<0.01）、反射恢复时间显著减少（MD=-2.14，95% CI=-3.31～-1.56，P<0.01）和肌张力恢复时间显著减少（MD=-2.46，95% CI=-3.99～-1.13，P<0.01）、随访后遗症发生率显著减少（RR=0.23，95% CI=0.11～0.46，P<0.01）；按照对照组干预措施不同采用亚组分析结果基本一致。结论 神经节苷脂联用纳洛酮治疗新生儿HIE科有效改善NBNA评分，缩短临床体征恢复时间，减少后遗症的发生。

Objective To evaluate the efficacy and safety of ganglioside combined with naloxone in the treatment of neonatal with hypoxic ischemic encephalopathy (HIE). Methods The randomized controlled trials(RCT) related to ganglioside combined with naloxone in the treatment of HIE were electronically searched PubMed,EMBASE,Cochrane library, CBM, CNKI, VIP and Wanfang Database form establishement to March 2019. Meta-analysis was performed by RevMan 5.3. Results Fifteen RCTs involving 1 116 infants with HIE were included. Meta-analyses showed that, compared with the control group, the treatment group of the effective rate was higher (RR=1.25, 95%CI=1.18-1.33, P<0.01), the NBNA mark was improved (MD=4.24, 95%CI=3.72-4.76, P<0.01), conscious recovery time was reduced (MD=-2.13, 95%CI=-2.54--1.71, P<0.01), the reflex recovery time was reduced (MD=-2.14, 95%CI=-3.31--1.56, P<0.01) and the muscle tension recovery time was reduced (MD=-2.46, 95%CI=-3.99--1.13, P<0.01) and with lower occurrence rate of sequelae of nerve system (RR=0.23, 95%CI=0.11-0.46, P<0.01). Subgroup analysis results were basically consistent according to different interventions in the control group. Conclusion Ganglioside combined with naloxone in the treatment of neonatal with HIE can effectively improve NBNA score, shorten the recovery time of clinical signs and reduce the occurrence of sequelae.