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[摘要]
目的 研究左卡尼汀口服溶液联合阿魏酸哌嗪片对糖尿病肾病患者的治疗效果。方法 选择2015年6月—2018年6月榆林市第二医院收治的100例糖尿病肾病患者,随机分为两组。对照组口服阿魏酸哌嗪片治疗,2片/次,3次/d。观察组联合口服左卡尼汀口服溶液,10 mL/次,2次/d。两组患者均治疗4周。观察两组患者的临床疗效,同时比较两组治疗前后的血清炎症因子、24 h尿蛋白定量、尿白蛋白排泄率、血肌酐、血尿素氮以及肌酐清除率。结果 治疗后,观察组的总有效率为86.00%,明显高于对照组的70.00%,两组比较差异有统计学意义(P<0.05)。两组治疗后的血清白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)水平均明显降低,同组治疗前后比较差异有统计学意义(P<0.05);且观察组明显低于对照组,差异有统计学意义(P<0.05)。两组治疗后的24 h尿蛋白定量、尿白蛋白排泄率以及肌酐清除率均明显降低,血肌酐、血尿素氮水平升高,同组治疗前后比较差异具有统计学意义(P<0.05);且观察组肾功能指标明显优于对照组,两组比较差异有统计学意义(P<0.05)。结论 左卡尼汀口服溶液联合阿魏酸哌嗪片有助于提高糖尿病肾病患者的治疗效果,改善患者的微炎症状态和肾功能,值得推广应用。
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[Abstract]
Objective To investigate the effect of Levocarnitine Oral Solution combined with Piperazine Ferulate Tablets on patients with diabetic nephropathy. Methods Selected 100 cases of patients with diabetic nephropathy who were treated in Yulin Second Hospital from June 2015 to June 2018 were divided into two groups randomly. The control group was treated with Piperazine Ferulate Tablets, 2 tablets/time, three times daily. Patients in the observation group were po administered with Levocarnitine Oral Solution, 10 mL/time, twice daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacy in two groups were observed, and the serum inflammatory factors, 24 h urinary protein, urinary albumin excretion rate, serum creatinine, blood urea nitrogen, and creatinine clearance rate before and after treatment were compared. Results After treatment, the effective rate of the observation group was 86.00%, which was significantly higher than 70.00% in the control group, and there were differences between two groups (P<0.05). After treatment, the serum levels of IL-6, TNF-α, and CRP in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the indexes in observation group were significantly lower than those in the control group, with significant differences between two groups (P<0.05). After treatment, the 24 h urine protein quantitative, urinary albumin excretion rate, and creatinine clearance rate in two groups were significantly decreased, but the serum creatinine and blood urea nitrogen were incresead, and the difference was statistically significant in the same group (P<0.05). And the renal indexes in the observation group were obviously better than those in the control group (P<0.05). Conclusion Levocarnitine Oral Solution combined with Piperazine Ferulate Tablets can help improve the therapeutic effect of diabetic nephropathy patients, and improve their micro inflammatory state and renal function, which has a certain clinical application value.
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