目的 对疏风解毒胶囊进行拆方研究，研究清热解毒组分、解表组分及其配伍组合分别对急性肺炎模型大鼠血清细胞因子水平的影响，从而分析疏风解毒胶囊配伍合理性。方法 制备肺炎链球菌致肺炎大鼠模型，分为对照组、模型组、头孢氨苄组、疏风解毒胶囊全方组（全方组）、疏风解毒胶囊解表组（解表组）、疏风解毒胶囊清热解毒组（清热解毒组），连续给药6 d，检测各组大鼠血清中白细胞介素-1α（IL-1α）、IL-1β、IL-2、IL-4、IL-6、IL-10、肿瘤坏死因子-α（TNF-α）、α干扰素（IFN-α）、IFN-γ水平，评价组方配伍的合理性。结果 疏风解毒胶囊全方、解表组分、清热解毒组分均能显著降低IL-1α、IL-1β、IL-2、IL-4、IL-10水平，全方组大鼠在IL-1β水平上Q值>1；疏风解毒胶囊全方、解表组分、清热解毒组分均能显著降低TNF-α、IFN-γ水平，疏风解毒胶囊全方、解表组分能显著降低IFN-α水平；全方组大鼠在TNF-α、IFN-α水平这2个指标上Q值>1。结论 疏风解毒胶囊有显著的调节免疫功能的作用，解表组分和清热解毒组分有显著的协同作用。

Objective In order to study the decomposed on separated complex prescription of Shufeng Jiedu Capsule (SJC) and analyze the compatibility rationality, the effects of heat-clearing and toxin-removing component, exterior-releasing component and their combination on serum cytokines content of rats with acute pneumonia were studied. Methods The pneumonia model of rats induced by Streptococcus pneumoniae was used, wich were divided into control group, model group, cephalexin group, SJC whole prescription group (whole prescription group), SJC exterior-releasing group (exterior-releasing group), SJC heat-clearing and toxinremoving group (heat-clearing and toxin-removing group). After administration for 6 days, content of IL-1α, IL-1β, IL-2, IL-4, IL-10, TNF-α, IFN-α, and IFN-γ was tested to evaluate the compatibility rationality. Results The content of IL-1α, IL-1β, IL-2, IL-4 and IL-10 was significantly reduced by the whole prescription, the exterior-releasing component and the heat-clearing and toxinremoving components of SJC. The Q value of rats in the whole prescription group was beyond 1 on the content of IL-1β. The content of TNF-α and IFN-γ was significantly reduced by the whole prescription, the exterior-releasing components and the heatclearing and toxin-removing component of SJC. The content of IFN-α was significantly reduced by the whole prescription, the relieving exterior component of SJC. The Q values of rats in the whole prescription group were beyond 1 on the content of TNF-α and IFN-α. Conclusion SJC has significant immunomodulatory effect and has a significant therapeutic effect on Streptococcus pneumoniae infection in rats. The exterior-releasing component and the heat-clearing and toxin-removing component have significant synergistic effects.

国家中药标准化专项资助（ZYBZH-C-AH-02）；国家自然科学基金资助项目（81430096）；国家自然科学基金资助项目（81703802）