目的 探讨疏风解毒胶囊免疫调节作用机制。方法 采用肺炎链球菌致肺炎大鼠模型，观察疏风解毒胶囊给药后对淋巴细胞分类，细胞因子白细胞介素-1α（IL-1α）、IL-1β、IL-2、IL-4、IL-6、IL-10、肿瘤坏死因子-α（TNF-α）、α干扰素（IFN-α）、γ干扰素（IFN-γ）水平，免疫球蛋白A（IgA）、免疫球蛋白M（IgM）、免疫球蛋白G（IgG）水平，胸腺、脾脏、肺脏质量的影响。结果 疏风解毒胶囊能显著降低模型大鼠外周血B淋巴细胞比例、CD8⁺比例，降低血清IL-1α、IL-1β、IL-2、IL-10、TNF-α、IFN-α、IFN-γ、IgM、IgG水平，降低肺炎大鼠胸腺、脾脏、肺脏质量，升高外周血CD4⁺/CD8⁺及NK细胞比例。结论 疏风解毒胶囊有显著的免疫调节作用，其通过降低B淋巴细胞、CD8⁺比例及IL-1α、IL-1β、IL-2、IL-10、TNF-α、IFN-α、IFN-γ、IgM、IgG水平，降低肺炎大鼠胸腺、脾脏、肺脏质量，升高CD4⁺/CD8⁺及NK细胞比例对肺炎模型大鼠有显著的治疗作用。

Objective To explore the immunoregulation of Shufeng Jiedu Capsule (SJC) and its mechanism. Methods Using the Streptococcus pneumoniae (SP)-induced pneumonia rats model to study the immunoregulation of SJC, collecting peripheral blood and serum to measure the factors related to immune response such as lymphocyte classification, interleukin-1α (IL-1α), interleukin-1β (IL-1β), interleukin-2 (IL-2), interleukin-4 (IL-4), interleukin-6 (IL-6), interleukin-10 (IL-10), tumor necrosis factor (TNF-α), interferon-α (IFN-α), interferon-γ (IFN-γ), immunoglobulin A (IgA), immunoglobulin M (IgM), immunoglobulin G (IgG), and the weight of thymus, spleen and lung. Results SJC can significantly decrease B cell (%) and CD8⁺(%) in peripheral blood, decrease the levels of IL-1α, IL-1β, IL-2, IL-10, TNF-α, IFN-α, IFN-γ, IgM, and IgG in serum, reduce the weight of thymus, spleen, and lung. It also increased the content of CD4⁺/CD8⁺ and NK cell (%) in peripheral blood. Conclusion SJC has significant immunomodulatory effect and shows significant therapeutic effect on pneumonia model rats by decreasing the content of B cell (%), CD8⁺(%), IL-1α, IL-1β, IL-2, IL-10, TNF-α, IFN-α, IFN-γ, IgM, and IgG, reducing the weight of thymus, spleen and lung, and increasing the content of CD4⁺/CD8⁺ and NK cell (%) in peripheral blood.

国家中药标准化专项资助（ZYBZH-C-AH-02）；国家自然科学基金资助项目（81430096）；国家自然科学基金资助项目（81703802）