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[摘要]
目的 探讨疏风解毒胶囊免疫调节作用机制。方法 采用肺炎链球菌致肺炎大鼠模型,观察疏风解毒胶囊给药后对淋巴细胞分类,细胞因子白细胞介素-1α(IL-1α)、IL-1β、IL-2、IL-4、IL-6、IL-10、肿瘤坏死因子-α(TNF-α)、α干扰素(IFN-α)、γ干扰素(IFN-γ)水平,免疫球蛋白A(IgA)、免疫球蛋白M(IgM)、免疫球蛋白G(IgG)水平,胸腺、脾脏、肺脏质量的影响。结果 疏风解毒胶囊能显著降低模型大鼠外周血B淋巴细胞比例、CD8+比例,降低血清IL-1α、IL-1β、IL-2、IL-10、TNF-α、IFN-α、IFN-γ、IgM、IgG水平,降低肺炎大鼠胸腺、脾脏、肺脏质量,升高外周血CD4+/CD8+及NK细胞比例。结论 疏风解毒胶囊有显著的免疫调节作用,其通过降低B淋巴细胞、CD8+比例及IL-1α、IL-1β、IL-2、IL-10、TNF-α、IFN-α、IFN-γ、IgM、IgG水平,降低肺炎大鼠胸腺、脾脏、肺脏质量,升高CD4+/CD8+及NK细胞比例对肺炎模型大鼠有显著的治疗作用。
[Key word]
[Abstract]
Objective To explore the immunoregulation of Shufeng Jiedu Capsule (SJC) and its mechanism. Methods Using the Streptococcus pneumoniae (SP)-induced pneumonia rats model to study the immunoregulation of SJC, collecting peripheral blood and serum to measure the factors related to immune response such as lymphocyte classification, interleukin-1α (IL-1α), interleukin-1β (IL-1β), interleukin-2 (IL-2), interleukin-4 (IL-4), interleukin-6 (IL-6), interleukin-10 (IL-10), tumor necrosis factor (TNF-α), interferon-α (IFN-α), interferon-γ (IFN-γ), immunoglobulin A (IgA), immunoglobulin M (IgM), immunoglobulin G (IgG), and the weight of thymus, spleen and lung. Results SJC can significantly decrease B cell (%) and CD8+(%) in peripheral blood, decrease the levels of IL-1α, IL-1β, IL-2, IL-10, TNF-α, IFN-α, IFN-γ, IgM, and IgG in serum, reduce the weight of thymus, spleen, and lung. It also increased the content of CD4+/CD8+ and NK cell (%) in peripheral blood. Conclusion SJC has significant immunomodulatory effect and shows significant therapeutic effect on pneumonia model rats by decreasing the content of B cell (%), CD8+(%), IL-1α, IL-1β, IL-2, IL-10, TNF-α, IFN-α, IFN-γ, IgM, and IgG, reducing the weight of thymus, spleen and lung, and increasing the content of CD4+/CD8+ and NK cell (%) in peripheral blood.
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[基金项目]
国家中药标准化专项资助(ZYBZH-C-AH-02);国家自然科学基金资助项目(81430096);国家自然科学基金资助项目(81703802)