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[摘要]
糖皮质激素(GC)具有强大的抗炎作用,是临床上使用最为广泛的免疫抑制剂,然而部分患者在使用激素治疗一段时间后会出现激素抵抗性。巨噬细胞移动抑制因子(MIF)是截至目前被认为唯一能负向调节GC抗炎作用的细胞因子,但MIF在糖皮质激素抵抗机制中扮演什么样的角色,尚未完全阐明。对MIF参与抵抗糖皮质激素抗炎作用的机制进行综述。
[Key word]
[Abstract]
With strong anti-inflammatory effect, glucocorticoid (GC) is clinically the most widely used immunosuppressant. However, some patients shows steroid resistance and do not achieve an effective response with GC treatment. Macrophage migration inhibitory factor is considered as the only factor which could negatively regulate the anti-inflammatory effect of GC, but the underlying mechanism is still not clear. The paper aims to review the role of macrophage migration inhibitory factor in resistance mechanism of glucocorticoid in inflammatory diseases.
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