目的 探讨知柏地黄丸联合亮丙瑞林治疗女童中枢性性早熟的效果分析。方法 选取2015年11月-2017年11月西安市儿童医院收治的中枢性性早熟女童61例，采用随机数字表法将患儿分为两组，对照组患儿给予亮丙瑞林，观察组在对照组的基础上给予知柏地黄丸，比较两组患儿的临床治疗效果及骨龄指数，B超观察两组患儿的乳房转归情况、子宫容积、卵巢容积和卵泡直径变化趋势。结果 两组患儿治疗的总有效率比较无统计学差异；治疗前后两组患儿的骨龄指数比较及组间比较无统计学差异。观察组患儿乳房转归有效率显著高于对照组（P<0.05）。治疗后两组患儿的子宫容积、卵巢容积和卵泡直径均显著下降（P<0.05），且观察组显著低于对照组（P<0.05）。两组患儿治疗期间均未出现不良反应，且肝肾功能检查均在正常范围内。结论 知柏地黄丸联合亮丙瑞林治疗女童中枢性性早熟的乳房转归有效率较高，并可显著改善患儿的子宫容积、卵巢容积和卵泡直径，延缓且不良反应较少，安全性较高。

Objective To investigate the effect of Zhibai Dihuang Pill combined with leuprorelin in the treatment of central precocious puberty in girls.Methods 61 cases of central precocious puberty girls were selected from November 2015 to November 2017 in our hospital, and were divided into two groups by random number table method. The control group was given leuprorelin, and the observation group was given Zhibai Dihuang Pills on the basis of the control group. The clinical therapeutic effect and bone age index of the two groups were compared, and the breast outcome, uterine volume, ovarian volume and follicular diameter of the two groups were observed by ultrasound. Results There was no significant difference in the total effective rate between the two groups. There was no significant difference in bone age index between the two groups before and after treatment. The breast conversion efficiency of the observation group was significantly higher than that of the control group (P<0.05). There were no significant differences in uterine volume, ovarian volume and follicular diameter between the two groups before treatment. After treatment, both groups were significantly decreased, and the observation group was significantly lower than the control group (P<0.05). No adverse reactions were found in the two groups during treatment, and the liver and kidney function tests were within the normal range.Conclusion Zhibai Dihuang Pill combined with leuprorelin in the treatment of girls with central precocious puberty has a higher breast conversion efficiency, and can significantly improve the uterine volume, ovary volume and follicular diameter of the children, delay and less adverse reactions, higher safety.

陕西省社会发展科技攻关项目（2015SF215）