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[摘要]
目的 研究丹参酮ⅡA磺酸钠联合重组人脑利钠肽治疗心肌梗死的临床疗效、心功能改善情况和预后。方法 选择2015年1月-2017年12月铜川市人民医院收治的158例心肌梗死患者作为研究对象,将患者随机分为两组,每组各79例。对照组iv重组人脑利钠肽,观察组在对照组的基础上静脉滴注丹参酮ⅡA磺酸钠注射液,两组均治疗14 d。观察两组患者的临床疗效,同时比较两组治疗前后的心功能指标、血清学指标和预后情况。结果 治疗后,观察组的总有效率为91.14%,明显高于对照组的77.21%(P<0.05)。治疗后,两组患者左心室射血分数(LVEF)均明显升高,左心室舒张末期内径(LVDd)及左心室后壁厚度(LVPWT)明显降低(P<0.05);且观察组心功能指标显著优于对照组(P<0.05)。治疗后,两组的超氧化物歧化酶(SOD)水平明显升高,心肌肌钙蛋白(cTnI)、肌酸激酶同工酶(CK-MB)及内皮素-1(ET-1)水平均显著降低(P<0.05);且观察组血清学指标水平明显优于对照组(P<0.05)。治疗后,观察组再梗死、心源性休克、心律失常以及心绞痛的发生率均明显低于对照组(P<0.05)。结论 丹参酮ⅡA磺酸钠联合重组人脑利钠肽治疗心肌梗死的疗效显著,有助于改善患者的心功能指标,且预后效果较为满意。
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[Abstract]
Objective To study the effect of sodium tanshinone Ⅱ A sulfonate combined with recombinant human brain natriuretic peptide in treatment of myocardial infarction, improvement of cardiac function and prognosis. Methods 158 cases of patients with myocardial infarction in Tongchuan People's Hospital from January 2015 to December 2017 were randomly divided into two groups, each group had 79 cases. The control group was intravenously injected with recombinant human brain natriuretic peptide, and the observation group was given intravenous drip of sodium tanshinone Ⅱ A sulfonate, Patients in two groups were treated for 14 d. After treatment, the clinical efficacy was evaluated, and cardiac function indexes, serological indexes, and prognosis in two groups before and after treatment were compared. Results After treatment, the effective rate of the observation group was 91.14%, which was significantly higher than 77.21% in the control group (P<0.05). After treatment, LVEF in two groups were significantly increased, but the LVDd and LVPWT were decreased (P<0.05), and cardiac function indexes in the observation group were better than those in the control group (P<0.05). After treatment, the SOD level in the two groups were increased significantly, but the levels of cTnI, CK-MB and ET-1 in the two groups were significantly decreased (P<0.05), and serological indexes in the observation group were better than those in the control group (P<0.05). The incidence of re infarction, cardiogenic shock, arrhythmia and angina pectoris in the observation group were significantly lower than control group (P<0.05). Conclusions The effect of sodium tanshinone Ⅱ A sulfonate combined with recombinant human brain natriuretic peptide in treatment of myocardial infarction is curative, and it is helpful to improve the cardiac function of the patients, and the prognosis is satisfactory.
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