[关键词]
[摘要]
果蝇作为广泛应用于衰老研究领域的模式生物,与其他衰老的动物模型相比较,果蝇衰老模型具有生长周期短,繁殖力强,雌雄易分辨,实验操作简单的优点,能够保证足够的数量以及足够的空间进行实验,同时还有基因保守性高等特点,因此是一种常用的衰老模式生物,近些年其在加快抗衰老药物的筛选速度和衰老的机制研究等方面显示出潜在的应用价值。对果蝇衰老模型的建立方法、给药方式、药效学评价、抗衰老通路及果蝇在部分抗衰老中药中的应用5个方面进行综述,分别介绍了5种果蝇衰老模型,不同的给药方式以及行为学,生化指标和代谢组学方面的研究,分析了模式生物果蝇与衰老相关的信号通路和机制,列举了的部分抗衰老中药在衰老模式生物果蝇中的应用,为今后衰老机制的研究、抗衰老中药物和保健品的开发等提供理论依据和实验参考。
[Key word]
[Abstract]
Drosophila is a model organism widely used in the field of aging research. Compared with other aging animal models, Drosophila aging model has easy feeding, short growth cycle, strong fertility, easy to distinguish between male and female, simple experimental operation, and sufficient to ensure sufficient The quantity and sufficient space for experiments, as well as the high degree of gene conservation, are a common aging model organism. In recent years, it has shown potential in accelerating the screening speed of anti-aging drugs and the mechanism of aging. Value. In this paper, the establishment methods, mode of administration, pharmacodynamic evaluation, anti-aging pathway and application of Drosophila in some anti-aging Chinese medicines were reviewed. Five fruit fly aging models were introduced. The mode of administration, as well as behavioral, biochemical and metabolomic studies, analyzed the signaling pathways and mechanisms associated with aging in Drosophila, and listed some of the anti-aging Chinese medicines used in aging model organisms. Provide theoretical basis and experimental reference for the research of aging mechanism, the development of anti-aging drugs and health products.
[中图分类号]
[基金项目]
山西省重点研发计划项目(201703D321023-3);山西省科技基础条件平台建设项目(2014091022)。