[关键词]
[摘要]
近年来,欧盟因为对乙酰氨基酚缓释制剂的安全性问题已经暂停其在欧盟国家的销售,目前国内对于对乙酰氨基酚缓释制剂的安全性罕见报道。结合对乙酰氨基酚缓释制剂的发展历史,对正常剂量和过量使用对乙酰氨基酚缓释制剂、曲马多-对乙酰氨基酚复方缓释制剂的安全性和药动学参数等方面进行详细论述,为含对乙酰氨基酚的缓释制剂的安全性评价和合理应用提供参考。
[Key word]
[Abstract]
In recent years, sustained release formulation of paracetamol has been discontinued in EU market because of its safety issue, but the safety of this drug is rarely reported in China. This review expounds the safety as well as pharmacokinetics parameters of sustained release paracetamol formulation and extended release tramadol/paracetamol formulation following therapeutic dose and overdose combining with the history of drug development,which provide a clue for safety evaluation and rational use of these drugs.
[中图分类号]
R943;R965.3
[基金项目]