目的 探讨丹参多酚酸盐注射液对高龄冠心病患者心肌缺血及心率变异性的影响。方法 选择宝鸡市中心医院2016年4月-2018年5月收治的78例高龄冠心病心肌缺血患者，根据随机数字表法分为观察组及对照组。对照组给予常规治疗，观察组在对照组基础上加用丹参多酚酸盐。观察两组治疗前后的ST段压低总次数、总时间、24 h正常RR间期标准差（SDNN）、24 h内每5分钟正常RR间期平均值标准差（SDANN）、心电图疗效及心率变异性改善疗效，观察两组心功能指标[左室射血分数（LVEF）、心输出量（CO）、B型利钠肽（BNP）]及不良反应。结果 治疗前，两组的ST段压低总次数、ST段压低总时间对比无统计学意义；治疗后两组的ST段压低总次数、ST段压低总时间均明显下降，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗后观察组明显低于对照组，差异有统计学意义（P<0.05）。观察组的心电图总有效率明显高于对照组，组间差异有统计学意义（P<0.05）。治疗前，两组的SDNN、SDANN对比无统计学意义；治疗后，对照组与治疗前对比无统计学意义；观察组的SDNN、SDANN明显高于治疗前及对照组，差异有统计学意义（P<0.05）。治疗前，两组的LVEF、CO、BNP水平对比无统计学意义；治疗后，两组的LVEF、CO明显上升，BNP明显降低，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗后观察组LVEF、CO明显高于对照组，BNP明显低于对照组，组间差异有统计学意义（P<0.05）。两组不良反应对比无统计学意义。结论 丹参多酚酸盐注射液可显著改善高龄冠心病患者的心肌缺血及心率变异性，且用药安全，值得临床推广应用。

Objective To investigate the effect of Danshen Polyphenolate Injection on myocardial ischemia and heart rate variability in elderly patients with coronary heart disease. Methods 78 elderly patients with coronary heart disease from April 2016 to May 2018 in our hospital were chosen and divided into the observation group and control group. The control group were given conventional treatment, the observation group were given Danshen Polyphenolate Injection on the base of control group, the ST total number times, total time, SDNN, SDANN of two groups before and after treatment, the electrocardiogram efficacy and heart rate variability improved efficacy of two groups had no significant difference. After treatment, the ST total number times, total time, adverse reaction of two groups were compared. Results The ST total number times and total time of two groups before treatment had no significant difference. After treatment, the ST total number times and total time were decreased than before treatment, and the observation group was lower than control group (P<0.05); the electrocardiogram efficacy of observation group was higher than control group(P<0.05). The SDNN, SDANN of two groups before treatment had no significant difference. After treatment, the SDNN, SDANN of control group had no significant difference than before, the observation group were higher than before and control group (P<0.05). The LVEF, CO, BNP of two groups before treatment had no significant difference. After treatment, the LVEF, CO of two groups were obvious higher than before, and the observation group was higher than control group. After treatment, the BNP of two groups were obvious lower than before, the observation group was lower than control group (P<0.05). The adverse reaction of two groups had no significant difference. Conclusion The Danshen Polyphenolate Injection could improve the myocardial ischemia and heart rate variability in elderly patients with coronary heart disease, and which was safe and could be worth of clinical promotion application.

R972