[关键词]
[摘要]
目的 探讨结核丸联合环丝氨酸治疗耐药性肺结核的临床效果以及对患者炎性因子水平的影响。方法 将西安市胸科医院自2015年1月-2017年12月确诊的耐药性肺结核患者106例作为研究对象,按随机法分为观察组和对照组各53例,观察组使用结核丸联合环丝氨酸进行治疗,对照组仅使用环丝氨酸进行治疗,对比观察两组患者的临床疗效和体内炎性因子水平的变化情况。结果 治疗后两组患者痰细菌学转阴率分别为66.04%和62.26%,组间比较差异无统计学意义。治疗后观察组患者病灶吸收有效率为86.79%,明显高于对照组的73.58%,差异有统计学意义(P<0.05)。治疗后两组患者干扰素-γ(INF-γ)水平明显升高,白介素-4(IL-4)、C反应蛋白(CRP)和肿瘤坏死因子-α(TNF-α)水平均明显降低,同组治疗前后比较差异有统计学意义(P<0.05);其中观察组患者改善程度明显优于对照组,差异有统计学意义(P<0.05)。结论 使用结核丸联合环丝氨酸治疗耐药性肺结核患者可有效提高患者治疗效果,降低机体内炎性反应,可推广使用。
[Key word]
[Abstract]
Objective To investigate the clinical effect of tuberculous pill combined with cycloserine in the treatment of drugresistant pneumonia and its influence on the level of inflammatory factors. Methods 106 cases of drug-resistant pulmonary tuberculosis confirmed in our hospital from January 2015 to December 2017 were divided into study group and 53 cases in control group. The study group was treated with tuberculosis pill combined with cycloserine. The control group was treated with only cycloserine, and the clinical efficacy of the two groups was compared. And the changes in the levels of inflammatory factors in the body. Results after treatment, the negative rate of phlegm bacteriology was 66.04% and 62.26%, respectively, and there was no significant difference between the two groups. The effective rate of focus absorption was 86.79% after treatment, which was significantly higher than that in the control group 73.58% (P<0.05), and the level of INF-gamma in the two groups after treatment was obvious. The levels of IL-4, CRP and TNF-alpha were significantly decreased, and the improvement of the patients in the study group was significantly better than that of the control group (P<0.05). Conclusion The use of tuberculosis pills and cycserine in the treatment of drug-resistant pulmonary tuberculosis can effectively improve the therapeutic effect of the patients and reduce the inflammatory reaction in the body. It is a safe and effective Chinese patent medicine, which can be popularized.
[中图分类号]
R978.3
[基金项目]