目的 探讨丙种球蛋白联合α1b干扰素治疗儿童EB病毒感染的效果。方法 选择佛山市南海区妇幼保健院2015年1月-2018年12月收治的80例EB病毒感染患儿，根据随机数字表法，将所有患儿分为观察组（45例）及对照组（45例），两组患儿均给予抗感染、补液等对症治疗，对照组在对症治疗基础上给予α1b干扰素，观察组在对照组基础上加用丙种球蛋白。对比两组患儿的治疗效果、临床症状改善时间、EB-DNA转阴率、患儿治疗前后的T淋巴细胞亚群水平及治疗过程中不良反应。结果 观察组的总有效率为97.8%，对照组为82.2%，观察组的总有效率显著高于对照组（P<0.05）。观察组的体温下降时间、淋巴结消退时间、咽部体征消失时间、异型淋巴细胞恢复正常时间均显著低于对照组（P<0.05）。治疗后，两组患儿的CD4⁺、CD4⁺/CD8+显著上升，CD8+显著下降（P<0.05）；且观察组改变幅度显著优于对照组（P<0.05）；观察组的EB-DNA转阴率显著高于对照组（P<0.05）。两组治疗过程中不良反应发生情况无统计学差异。结论 与单独应用α1b干扰素相比，丙种球蛋白联合α1b干扰素治疗儿童EB病毒感染安全有效，可缩短患儿临床症状改善时间，提高转阴率及患儿免疫功能。

Objective To investigate the efficacy of α1b interferon combined with gamma globulin in treatment of children with EB virus infection. Methods 80 cases with EB virus infection from Jan. 2015 to Dec. 2018 in our hospital were chosen, who were divided to the observation group (45 cases) and control group (45 cases) according to random number table method. The children in two groups were given anti-infection, fluid and other symptomatic treatment, the control group were given atomized inhalation of alpha 1b interferon on the base of symptomatic treatment, the treatment effect, clinical symptom improvement time, EB-DNA conversion rate, T lymphocyte subsets and adverse reactions before and after treatment in two groups were compared. Results The total efficacy of observation group was higher than control group, the hypothermia time, lymph node regression time, pharyngeal signs disappearance time, and abnormal lymphocyte recovery time were all significantly lower than control group, the CD4⁺、CD4⁺/CD8⁺ of two groups were obvious higher, the CD8⁺ were obvious lower, and the changes of observation group were significantly higher than that of control group, the EB-DNA overcast rate of observation group was higher than control group, the adverse reaction of two groups had no significant difference. Conclusion Compared withα1b interferon interferon alone, α1b interferon combined with gamma globulin was safe and effective in treatment of EB virus infection in children, which could shorten the clinical symptoms improvement time, improve the rate of negative conversion and immune function of children.

R969

广东省中医药局项目（20171264）