[关键词]
[摘要]
注射用丹参多酚酸是以唇形科丹参药材为原料,采用现代先进工艺提取、分离其水溶性酚酸类有效成分研制而成的新一代中药注射剂。药理研究表明,丹参多酚酸对缺血性脑损伤具有抗炎、抗氧化应激、神经营养、再生和保护的作用,同时能够减轻心肌缺血损伤和糖尿病肾损伤。在临床上主要用于中风病(轻中度脑梗死)恢复期瘀血阻络证的治疗,近年来也逐步拓展应用到了急性脑梗死、呼吸综合征等方面的治疗。主要对注射用丹参多酚酸上市以来的药理作用、临床应用及安全性评价加以综述,为进一步开展基础试验提供研究线索,为临床推广应用提供参考依据。
[Key word]
[Abstract]
Salvianolic Acids for Injection (SAFI) using Salvia miltiorrhiza as raw material is a new generation of traditional Chinese medicine injection which is made by modern advanced technology to extract and separate the effective components of water-soluble phenolic acids. Modern pharmacological research shows that SAFI has the pharmacological effects of anti-inflammatory, antioxidative stress, neurotrophic, regeneration and protective effects on ischemic brain injury. At the same time, it can reduce myocardial ischemia and diabetic kidney injury. It is mainly used for the treatment of stroke (mild to moderate cerebral infarction). In recent years, it has also been gradually extended to the treatment of acute cerebral infarction and respiratory syndrome. Pharmacological action, clinical application, and safety evaluation of SAFI were reviewed in this article, to provide a clue for the further development of the basic research and a reference for the clinical application.
[中图分类号]
[基金项目]
天津市中药注射剂关键技术校企协同创新实验室建设(17PTSYJC00090)