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[摘要]
目的 观察注射用丹参多酚酸治疗急性期脑梗死的临床疗效及安全性。方法 124例急性期脑梗患者随机分为观察组、对照组,各62例。对照组给予抗血小板聚集、调控血脂、改善循环、营养神经、控制血压血糖及对症支持治疗脑梗死的药物治疗,必要时应用脱水剂;观察组在对照组治疗基础上加用注射用丹参多酚酸0.13 g溶于0.9%的氯化钠溶液250 mL缓慢静脉滴入,1次/d,共14 d。比较两组治疗前后美国国立卫生研究院卒中量表(NIHSS)评分、日常生活能力量表(Barthel Index,BI)评分改善的情况,患者治疗前后分别进行肝、肾功能化验,评价其安全性。结果 观察组与对照组治疗前NIHSS评分及BI评分比较差异没有统计学意义;治疗后,两组患者NIHSS评分显著降低,BI评分显著升高,治疗前后差异均具有统计学意义(P<0.05);治疗后,与对照组比较,观察组患者BI评分显著升高,NIHSS评分显著降低,差异具有统计学意义(P<0.05)。治疗后,观察组患者的总有效率是79.03%,显著高于对照组的45.16%,差异具有统计学意义(P<0.05)。两组患者在用药期间未出现严重不良反应。结论 注射用丹参多酚酸可明显改善急性脑梗死患者的神经功能,提高患者的生活质量,是治疗急性脑梗死安全有效的方法。
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[Abstract]
Objective To observe the clinical efficacy and safety of Salvianolic acid for Injection in the treatment of acute cerebral infarction. Methods Tatolly 124 patients with acute cerebral infarction were randomly divided into observation group and control group (n=62). Patiens in control group was given anti-platelet aggregation, regulating blood lipid, improving circulation, nourishing nerve, controlling blood pressure, blood sugar and symptomatic support to treat cerebral infarction, and dehydrating agent was used when necessary. Patiens in observation group was given salvianolic acid 0.13 g dissolved in 0.9% sodium chloride solution 250 mL intravenously, once a day for 14 days. NIHSS and Barthel Index score of the two groups were compared before and after treatment. Liver and kidney function tests were conducted before and after treatment to evaluate the safety of the two groups. Results There was no significant difference in NIHSS score and BI score between the observation group and the control group before treatment; after treatment, the NIHSS score of the two groups decreased significantly, BI score increased significantly, and the difference was statistically significant before and after treatment (P<0.05); after treatment, compared with the control group, the BI score of the observation group increased significantly, and the NIHSS score decreased significantly (P<0.05). After treatment, the total effective rate of the observation group was 79.03%, which was significantly higher than 45.16% of the control group (P<0.05). There were no serious adverse reactions in the two groups. Conclusion Salvianolic Acid for Injection can significantly improve the neurological function and quality of life of patients with acute cerebral infarction, which is a safe and effective method for the treatment of acute cerebral infarction.
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