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[摘要]
目的 观察注射用丹参多酚酸对脑梗死急性期患者血清可溶性细胞间黏附分子-1(sICAM-1)、可溶性血管细胞黏附分子-1(sVCAM-1)表达的影响。方法 将126例脑梗死急性期患者随机分为观察组和对照组,对照组采用常规治疗方法,进行抗血小板治疗:口服阿司匹林,每天100 mg,并辅以其他对症支持治疗。观察组在常规治疗基础上加注射用丹参多酚酸100 mg,用250 mL生理盐水稀释,静脉滴注,每天1次,连续14 d。应用酶联免疫吸附实验检测两组治疗前后血清中sICAM-1和sVCAM-1水平。结果 两组治疗前血清中sICAM-1和sVCAM-1的水平比较差异无统计学意义。治疗2周后观察组血清中sICAM-1和sVCAM-1的水平与治疗前比较均显著降低(P<0.001),且显著低于治疗后对照组(P<0.001)。对照组治疗前后无显著差异。结论 注射用注射用丹参多酚酸对于脑梗死急性期患者血清中sICAM-1和sVCAM-1水平有明确的降低作用。
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[Abstract]
Objective Effect of Salvianolic Acid for Injection on expression of serum Soluble Intercellular Adhesion Molecule-1 (s ICAM-1) and Soluble Vascular Cell Adhesion Molecule-1 (sVCAM-1) in patients with acute cerebral infarction. Methods Tatolly 126 patients with acute cerebral infarction were randomly divided into observation and control group. The control group was treated with routine therapy and antiplatelet therapy:oral aspirin, 100 mg per day, supplemented by other symptomatic supportive treatment. The observation group was treated with salvianolic acid 100 mg for injection, diluted with 250 mL saline, intravenously dripped once a day for 14 days. Enzyme-linked immunosorbent assay was used to examine the expression of sICAM-1 and sVCAM-1 in the serum of the two groups. Results There was no significant difference in the levels of sICAM-1 and sVCAM-1 between the two groups before treatment. The levels of sICAM-1 and sVCAM-1 in the serum of observation groups were significantly lower than those before treatment (P<0.05). The levels of sICAM-1 and sVCAM-1 in the serum of observation group were significantly lower compared with control group (P<0.05). Conclusions Salvianolic Acid for Injection has a clear effect on the levels of sICAM-1 and sVCAM-1 in the serum of patients with acute cerebral infarction.
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