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[摘要]
目的 探讨注射用丹参多酚酸在治疗脑小血管病时对患者认知功能障碍的影响。方法 选择80例脑小血管病患者,随机分为两组,对照组给予常规治疗方案,观察组在常规治疗方案的基础上给予注射用丹参多酚酸治疗。疗程均为2周,80例研究对象在治疗前后均进行MoCA评分,并观察治疗中的不良反应。结果 治疗前,两组MoCA评分及MMSE评分无差异;对照组治疗后的MoCA评分及MMSE评分较治疗前提高,但差异无统计学意义;观察组治疗后的MoCA评分及MMSE评分较治疗前提高,差异有统计学意义(P<0.05);观察组治疗后的MoCA评分及MMSE评分较对照组改善显著,两组间比较差异具有统计学意义(P<0.05)。两组治疗过程中均无明显不良反应。结论 注射用丹参多酚酸可有效改善脑小血管病患者的认知功能障碍,并且安全性良好。
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[Abstract]
Objects To investigate the effect of Salvianolic Acids for Injection on cognitive dysfunction in patients with cerebral small vessel disease. Methods Eighty patients with cerebral small vessel disease were randomly divided into two groups. The control group received a conventional treatment plan. The treatment group was given Salvianolic Acids for Injection on the basis of the conventional treatment plan. The treatment was two weeks. 80 patients underwent MoCA score before and after treatment, and observe the adverse reactions in the treatment. Results There was no difference in MoCA scores between the two groups before treatment. After treatment, the MoCA score of the control group was higher than that of the control group, but there was no significant difference, and the treatment was ineffective. After treatment, the MoCA score of the observation group was higher than that of the control group (P=0.025). After treatment, the MoCA score of the two groups was different (P=0.001). After treatment, the MoCA score of the observation group improved significantly compared with that of the control group. Conclusions Salvianolic Acids for Injection can effectively improve cognitive dysfunction in patients with cerebral small vessel disease and has good safety.
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