目的 探讨注射用丹参多酚酸对脑梗死的疗效及对血清神经元特异性烯醇化酶（NSE）、S-100β蛋白的影响。方法 选择2016年1月-2018年1月保定市第一中心医院接诊的急性脑梗死患者100例，按照入院时间先后顺序分为对照组和观察组，每组50例。对照组在常规治疗基础上加用银杏叶提取物注射液（舒血宁）静脉滴注，观察组在常规治疗基础上加用注射用丹参多酚酸静脉滴注。疗程均为14 d。比较两组疗效，治疗前后血清NSE、S-100β蛋白的变化及不良反应发生情况。结果 观察组和对照组在治疗前NIHSS评分无显著差异；在治疗14 d后，两组NIHSS评分水平均显著低于治疗前，同组治疗前后比较差异有统计学意义（P<0.05）。且观察组NIHSS下降值明显大于对照组，观察组NIHSS水平低于对照组，差异有统计学意义（P<0.05）。治疗前NSE、S-100β水平在观察组和对照组间均无显著差异；在治疗14 d后，两组NSE、S-100β水平均显著下降，同组治疗前后比较差异有统计学意义（P<0.05），且观察组NSE、S-100β水平下降值大于对照组，下降后NSE、S-100β水平低于对照组，差异有统计学意义（P<0.05）。结论 注射用丹参多酚酸治疗脑梗死效果良好，能有效降低NSE、S-100β蛋白水平。

Objective To investigate the effect of Salvianolic Acids for Injection on neuron-specific enolase (NSE) cytokines, S-100β protein and its curative effect in treatment of cerebral infarction. Methods A total of 100 patients with cerebral infarction admitted during January 2016 and January 2017 were divided into control group (n=50) and observation group (n=50) according to admission time. Based on conventional therapy, the control group was injected with extract of Ginkgo Biloba leaf intravenously, while the observation group was injected with Salvianolic Acids for Injection intravenously. The course of treatment in the two groups was 14 d. The curative effect, changes of serum NSE and S-100β protein, and incidence rate of adverse reactions were compared in the two groups before and after the treatment. Results There was no significant difference in NIHSS score between the observation group and the control group before treatment. After 14 days of treatment, the NIHSS score level of the two groups was significantly lower than that before treatment, and there was significant difference between the same group before and after treatment (P<0.05). The decrease of NIHSS in the observation group was significantly higher than that in the control group, and the level of NIHSS in the observation group was lower than that in the control group, the difference was statistically significant (P<0.05). Before treatment, the levels of NSE and S-100β had no significant difference between salvianolic acid group and control group. After 14 days of treatment, the levels of NSE and S-100β in both groups decreased significantly, and there was significant difference before and after treatment in the same group (P<0.05). The levels of NSE and S-100β in observation group were lower than those in control group, and the levels of NSE and S-100β in observation group were lower than those in control group (P<0.05). Conclusion Salvianolic Acids for Injection in treatment of cerebral infarction has good curative effect. It can effectively and reduce NSE and S-100β protein levels.