目的 探讨高压氧疗联合注射用丹参多酚酸治疗脑梗死的疗效及对患者血液流变学的影响。方法 选取2016年1月-2018年2月周口市中心医院收治的脑梗死患者80例，随机分为两组，两组患者均给予降血脂、降血压、改善微循环、降低颅内压、抗凝、抗血小板聚集及脑神经保护药等常规治疗。对照组应用注射用丹参多酚酸，将100 mg注射用丹参多酚酸与250 mL 0.9%的NaCl注射液混合后为患者静脉滴注，1次/d；观察组应用高压氧疗（氧疗压力为0.25~0.30 MPa，时间为3min；氧浓度为80%~90%，温度为18~25℃）联合注射用丹参多酚酸；1个疗程为14 d，连续治疗4个疗程。比较两组患者血细胞比容、全血低切黏度、全血高切黏度、血浆黏度、治疗疗效、巴塞尔（Barthel）指数、神经功能（CSS）分值、神经功能缺损（NIHSS）分值以及血清肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）、神经生长因子（NGF）浓度。结果 治疗后两组患者血细胞比容、全血低切黏度、全血高切黏度、血浆黏度均显著降低，同组治疗前后比较差异有统计学意义（P<0.05）；且观察组各指标均显著低于对照组（P<0.05）。观察组治疗疗效显著优于对照组（P<0.05）。治疗后两组患者Barthel指数明显升高，同组治疗前后比较差异有统计学意义（P<0.05）；且观察组显著高于对照组（P<0.05）。治疗后两组患者CSS分值、NIHSS分值明显降低，同组治疗前后比较差异有统计学意义（P<0.05）；且观察组显著低于对照组（P<0.05）。治疗后两组患者血清TNF-α、IL-6浓度均明显降低，同组治疗前后比较差异有统计学意义（P<0.05）；且观察组显著低于对照组（P<0.05）。治疗后两组患者血清NGF浓度均明显升高，同组治疗前后比较差异有统计学意义（P<0.05）；且观察组显著高于对照组（P<0.05）。结论 高压氧疗联合注射用丹参多酚酸治疗脑梗死疗效确切。

Objective To explore the efficacy of hyperbaric oxygen therapy combined with Salvianolic Acids for Injection in the treatment of cerebral infarction and its effect on the hemorheology of patients. Methods Tatolly 80 cases of cerebral infarction patients admitted to our hospital from January 2016 to February 2018 were selected and randomly divided into two groups. Patients in control group were treated with Salvianolic Acids for Injection, Salvianolic Acids for Injection was mixed with 250 mL 0.9% NaCl injection for intravenous drip once a day. One course of treatment was 14 days, and four consecutive courses of treatment were given. Patients in research group was treated with hyperbaric oxygen therapy combined with Salvianolic Acids for Injection. Compare two groups of patients with hematocrit, whole blood low shear viscosity, whole blood high shear viscosity, plasma viscosity, treatment efficacy, Barthel index, neurological (CSS) score, nerve function defect (NIHSS) score, serum tumor necrosis factor -α (TNF-α), interleukin-6 (IL-6), the nerve growth factor (NGF) concentration. Results The blood cell volume, total blood viscosity, total blood viscosity and plasma viscosity of study group were lower than those of control group (P<0.05). The curative effect of study group was better than that of control group (P<0.05). The Barthel index of study group was higher than that of control group (P<0.05). The CSS and NIHSS score of study group was lower than that of control group (P<0.05). TNF-α and IL-6 concentrations in study group were lower than those in control group (P<0.05). NGF concentration in study group was higher than that in control group (P<0.05). Conclusion Hyperbaric oxygen therapy combined with Salvianolic Acids for Injection is effective in the treatment of cerebral infarction.