目的 研究注射用丹参多酚酸对急性脑梗死患者血液流变学、凝血功能以及血清氧化低密度脂蛋白（ox-LDL）、降钙素原（PCT）、单核细胞趋化蛋白-1（MCP-1）、胰岛素样生长因子-1（IGF-1）水平的影响。方法 选取河南大学淮河医院诊治的94例急性脑梗死患者，随机分为对照组和观察组，每组47例。入院后所有患者均根据自身情况给予综合治疗，而观察组在此基础上加用注射用丹参多酚酸。治疗前和治疗14 d后对两组患者的血液流变学、凝血功能以及血清ox-LDL、PCT、MCP-1、IGF-1水平进行检测和比较。结果 治疗前，两组患者的各项指标之间均不存在统计学差异。治疗后，两组患者的血液流变学相关指标全血黏度（WBV）、血浆黏度（PV）、红细胞聚集指数（EAI）、红细胞变形指数（EDI）、红细胞比容（Hct）水平和凝血功能相关指标血小板计数（PLT）、纤维蛋白原（Fib）、D-二聚体（D-D）水平以及血清ox-LDL、PCT、MCP-1水平均显著降低，IGF-1水平显著升高，与同组治疗前存在统计学差异（P<0.05），两组之间水平也均存在统计学差异（P<0.05）。结论 对急性脑梗死患者在综合内科治疗的基础上加用注射用丹参多酚酸，不仅可以更加明显地改善患者的血液流变学和凝血功能，而且能够降低患者血清ox-LDL、PCT、MCP-1水平，提高IGF-1水平，值得临床上进一步研究。

Objective To study the influence of Salvianolic Acids for Injection on hemorheology, coagulation function and serum levels of ox-LDL, PCT, MCP-1 and IGF-1 in patients with acute cerebral infarction. Methods To choose 94 cases of acute cerebral infarction in our hospital, randomly divided into the control group and observation group, 47 cases in each group. All patients were given comprehensive treatment according to their own condition after admission, and the observation group were added Salvianolic Acids for Injection on the basis. Before and after 14 days of treatment, detected and compare the hemorheology, coagulation function and serum levels of ox-LDL, PCT, MCP-1 and IGF-1 in the two groups. Results Before treatment, there was no statistical difference in various indicators between the two groups. After treatment, the hemorheology ralated indexes in the levels of WBV, PV, EAI, EDI, Hct and the coagulation function related indexes in the levels of PLT, Fib, D-D and the serum levels of ox-LDL, PCT, MCP-1 in the two groups were significantly decreased, the levels of IGF-1 significantly increased, there was a statistical difference compared with the same group before treatment (P<0.05), and the difference between the two groups had statistical significance (P<0.05). Conclusion Salvianolic Acids for Injection was added to the patients with acute cerebral infarction on the basis of comprehensive medical treatment, it could improve the hemorheology and coagulation function of patients more obviously, and reduce the serum levels of ox-LDL, PCT, MCP-1, increase IGF-1 level, it was worthy for further clinical study.