目的 探讨尿毒清颗粒联合羟苯磺酸钙治疗慢性肾衰竭的疗效及对结缔组织生长因子（CTGF）、骨形态发生蛋白-7（BMP-7）的影响。方法 采用回顾性总结研究方法，2016年4月—2018年1月选择在安阳市第六人民医院进行维持性血液透析的慢性肾衰竭患者92例，根据治疗方法的不同分为观察组与对照组各46例，对照组给予羟苯磺酸钙治疗，观察组在对照组治疗的基础上给予尿毒清颗粒治疗，两组都治疗观察3个月，记录CTGF、BMP-7变化情况。结果 观察组的总有效率为97.8%，高于对照组的87.0%，对比差异有统计学意义（P<0.05）。治疗后两组血清血尿素氮（BUN）与肌酐（Scr）值都显著高于治疗前（P<0.05），治疗后观察组显著低于对照组（P<0.05）。治疗后两组血清CTGF值显著降低、BMP-7值显著升高，对比差异有统计学意义（P<0.05），治疗后观察组与对照组对比差异也有统计学意义（P<0.05）。治疗后观察组的人际关系敏感、抑郁、焦虑、精神病性、敌对性、恐怖、偏执、躯体化、强迫症状等评分低于对照组，对比差异有统计学意义（P<0.05）。结论 尿毒清颗粒联合羟苯磺酸钙治疗慢性肾衰竭能提高治疗效果，调节CTGF和BMP-7分泌平衡，改善患者的肾肾功能，提高患者的生活质量。

Objective To investigate the effects of Niaoduqing granule combined with calcium dobesilate on chronic renal failure and its effects on CTGF and BMP-7. Methods From April 2016 to January 2018, 92 patients with chronic renal failure in maintenance hemodialysis were selected in our hospital and were divided into the observation group and the control group of 46 cases in each groups accorded to the different treatment methods. The control group were given calcium hydroxybenzene sulfonate treatment, and the observation group were given Niao Du Qing granule combined with calcium dobesilate treatment, the two groups were treated for 3 months, and the changes of CTGF and BMP-7 were recorded. Results The total effective rate of the observation group were 97.8%, which was higher than that of the control group of 87%, and compared the difference were statistically significant (P < 0.05). After treatment, the serum BUN and Scr values of the two groups were significantly higher than those before treatment (P < 0.05), and the observation group were significantly lower than that of the control group (P < 0.05). After treatment, the value of CTGF in the two groups were decreased significantly and the value of BMP-7 were increased significantly, the difference compared between the observation group and the control group after treatment were also statistically significantly (P < 0.05). After treatment, the scores of interpersonal sensitivity, depression, anxiety, psychosis, hostility, horror, paranoia, somatization and compulsion were lower in the observation group than in the control group (P < 0.05). Conclusion Niao Du Qing granule combined with calcium dobesilate can improve the therapeutic effect, regulate the balance of CTGF and BMP-7, improve the renal function of the patients and improve the quality of life of the patients.