[关键词]
[摘要]
目的 应用Ames试验探讨泰格列净是否具有致突变性。方法 采用标准平板掺入法,应用组氨酸营养缺陷型鼠伤寒沙门氏菌TA97、TA98、TA100、TA102和TA1535对泰格列净进行回复突变试验。结果 在31.25~2 000μg/皿剂量范围内,加和不加大鼠肝微粒体酶S9平行条件下测试,泰格列净Ames回复突变试验结果为阴性。结论 在本试验条件下,泰格列净无致突变性。
[Key word]
[Abstract]
Objective To study the mutagenicity of Tianagliflozin in Ames assay. Methods Using the standard plate incorporation assay, the bacterial reverse mutation of Tianagliflozin was tested in the histidine defective strains of salmonella typhimurium TA97, TA98, TA100, TA102, and TA1535. Results In the presence and absence of rat liver microsome S9 mix, the results of assay were negative at the dose within 31.25-2 000 μg/plate. Conclusion The mutagenicity of Tianagliflozin was not observed in the assay.
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[基金项目]
国家科技重大新药创制项目(2015ZX09501004);天津市科技计划项目(16PTGCCX00090)