目的 分析胎盘多肽注射液联合mFOLFOX6方案对结直肠癌患者术后血脂及不良反应的影响。方法 选取云南省第三人民医院2015年3月-2017年3月收治的150例结肠癌患者，按照随机数字表法分为观察组、对照组，各75例，均行腹腔镜下结直肠癌根治术治疗，术后使用mFOLFOX6方案行辅助化疗，化疗方案每周期持续2周，患者共接受6个周期化疗；观察组在上述治疗方案的基础上，化疗期间加用胎盘多肽注射液静脉滴注。比较两组患者化疗1周期前后血脂变化、化疗期间不良反应发生情况及化疗结束后近期疗效，总结胎盘多肽注射液对患者术后血脂及不良反应的影响。结果 与化疗前1 d相比，两组患者化疗14 d后三酰甘油（TG）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）均升高，对照组化疗14 d后TG、LDL-C、HDL-C均高于观察组，差异有统计学意义（P<0.05）。化疗结束后，观察组、对照组临床总有效率分别为45.33%、42.67%，组间比较差异无统计学意义。化疗期间，观察组Ⅲ~Ⅳ度恶心/呕吐、外周神经毒性发生率低于对照组，其Ⅰ~Ⅱ度及Ⅲ~Ⅳ度口腔黏膜炎发生率均低于对照组，差异有统计学意义（P<0.05）。结论 将胎盘多肽注射液联合mFOLFOX6方案用于结肠癌术后辅助化疗，能够在保证化疗效果的基础上弱化化疗药物对脂质代谢的影响、降低不良反应发生率，从而有效提高化疗安全性。

Objective To analyze the effects of placental polypeptide injection combined with mFOLFOX6 on blood lipid and adverse reactions in patients with colorectal cancer after operation. Methods 150 cases of colon cancer patients in our hospital from March 2015 to March 2017 were randomly divided into observation group and control group, each 75 cases. All patients underwent laparoscopic radical resection for colorectal cancer, and the mFOLFOX6 regimen was used for adjuvant chemotherapy. The observation group received intravenous injection of placental polypeptide injection on the basis of the above treatment regimen during chemotherapy. The changes of blood lipid before and after chemotherapy, adverse reactions during chemotherapy and the short-term efficacy after chemotherapy were compared between the two groups. The effects of placental polypeptide injection on the blood lipids and adverse reactions were summarized. Results Compared with the 1 d before chemotherapy, the TG, LDL-C and HDL-C were elevated of the two groups after 14 d chemotherapy, the TG, LDL-C, HDL-C of the control group were higher than the observation group after 14 d chemotherapy, the difference was statistically significant (P<0.05). After chemotherapy, the total effective rate of the observation group and the control group was 45.33% and 42.67%, and there was no significant difference between the two groups. During chemotherapy, the Ⅲ-IV degree of nausea/vomiting, peripheral neurotoxicity rate of the observation group were lower than the control group, the I-Ⅱ and Ⅲ-IV degree of oral mucositis were lower than the control group, the difference was statistically significant (P<0.05). Conclusion The placenta polypeptide injection combined with mFOLFOX6 regimen for adjuvant chemotherapy after resection of colorectal cancer, can ensure the effect of chemotherapy on the basis of weakening effect of chemotherapeutic drugs on lipid metabolism, and reducing the incidence of adverse reactions, so as to effectively improve the safety of chemotherapy.