目的 了解黄石市妇幼保健院住院患者感染耐甲氧西林金黄色葡萄球菌（MRSA）的用药情况。方法 选取2015-2017年该院院内感染MRSA的住院病历410份，对标本来源、抗菌药名称、用法用量、疗程、联合用药及特殊级抗菌药物临床应用管理等进行调查，计算抗菌药物用药频度（DDDs）和药物利用度指数（DUI），并对不适宜用药进行总结。结果 410株MRSA标本主要来自于痰液（51.46%）、脓性分泌物（22.44%）和血液（12.44%）。410份病历中，共涉及6种抗菌药，其中替考拉宁使用最多（32.81%），其次为万古霉素（25.79%）和利奈唑胺（23.08%）；替考拉宁的DDDs最大（1 512.35），其次为利奈唑胺（922.83）和万古霉素（907.20），所有药物的DUI ≤ 1.0；用药不适宜病历57份（13.90%），主要为用法用量不适宜（25份，43.86%）和溶媒不适宜（16份，28.07%）；所有特殊级抗菌药物均未越级使用，但只有38份（9.27%）经专家会诊后使用。结论 万古霉素、替考拉宁和利奈唑胺是该院治疗MRSA感染的主要药物，且临床使用较好，不存在滥用倾向，但也有必要进一步规范合理用药，延缓细菌耐药。

Objective To investigate the antibacterial utilization of methicillin resistant Staphylococcus Aureus (MRSA) infection in Huangshi Maternal and Child Health Care Hospital.Methods A total of 410 inpatients who infected MRSA in Huangshi Maternal and Child Health Care Hospital from 2015 to 2017 were selected. The sources of the specimens, antibiotics name, usage and dosage, medication course, drug combination, and clinical application management of special antibacterial drugs were investigated. The defined daily dose system (DDDs) and drug utilization index (DUI), were calculated, and summarized and the inappropriate use of drugs.were analyzedResults A total of 410 specimens of MRSA mainly came from sputum (51.46%), purulent discharge (22.44%), and blood (12.44%). Six kinds of antimicrobial agents were involved in the 410 cases, and the maximum usage was teicoplanin (32.81%), followed by vancomycin (25.79%) and linezolid (23.08%), the maximum of DDDs was teicoplanin (1512.35), followed by linezolid (922.83) and vancomycin (907.20), DUI of all drugs were ≤ 1.0. The 57 cases (13.90%) were inappropriate used, in which inappropriate usage and dosage (25 cases, 43.86%) and inappropriate solvent (16 cases, 28.07%) were the main types. All special grade antibacterial drugs were not leapfrog used, but only 38 cases (9.27%) were used after consultation by experts.Conclusion Vancomycin, teicoplanin, and linezolid are the mainstreams of treatment MRSA infection in Huangshi Maternal and Child Health Care Hospital, and the clinical use is better, and no tendency to abuse.But it is necessary to further standardize rational use of drugs and delay the pace of bacterial resistance.