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[摘要]
目的 探讨氨茶碱治疗小儿反复气管支气管炎非急性期的效果。方法 2011年1月-2016年12月选择在西安市中心医院诊治的小儿反复气管支气管炎非急性期患儿210例作为研究对象,根据随机信封抽签原则分为观察组与对照组各105例,对照组给予常规治疗,观察组在对照组基础上给予氨茶碱静滴治疗,两组都治疗观察7 d。比较两组临床疗效,观察两组的咳嗽、肺部罗音、喘息等症状消失时间,比较两组的肺功能和生活质量评分。结果 对照组总有效率为89.5%,观察组的总有效率为98.1%,观察组的总有效率明显高于对照组,差异有统计学意义(P<0.05)。观察组的咳嗽消失时间、肺部罗音消失时间与喘息消失时间都明显优于对照组,差异有统计学意义(P<0.05)。观察组与对照组治疗后的FEV1值分别为(87.22±6.39)%和(78.20±7.38)%,都明显好于治疗前的(67.20±7.20)%和(66.98±6.82)%,同组治疗前后比较差异有统计学意义(P<0.05);且观察组治疗后的FEV1值也明显高于对照组,差异有统计学意义(P<0.05)。观察组与对照组治疗后的生活质量评分分别为(36.44±5.14)分和(42.30±5.00)分,观察组评分低于对照组,差异有统计学意义(P<0.05)。结论 氨茶碱治疗反复气管支气管炎非急性期能促进临床症状的恢复,改善肺功能,促进提高治疗效果,改善总体生活质量,有很好的应用价值。
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[Abstract]
Objective To investigate the effects and mechanism aminophylline in the treatment of patients with non acute stage recurrent bronchitis.Methods From February 2013 to December 2016, 120 cases of children with non acute stage recurrent bronchitis in our hospital were selected as the research object, all the cases were divided into observation group and control group with 105 cases in each group accorded to the random draw envelope principle, the control group was given routine treatment, the observation group was given inhalation aminophylline treatment based on the treatment in control group, two groups observation on the treatment of 7 d.Results The total effective rate of the control group was 89.5%, the total effective rate of the observation group was 98.1%, and the total effective rate of the observation group was significantly higher than that of the control group (P < 0.05). The cough disappeared time, pulmonary rales disappeared time and wheezing disappearance time in the observation group were significantly better than the control group (P < 0.05). The FEV1 values in the observation group and the control group after treatment were (87.22 ±6.39)% and (78.20 ±7.38)% that were significantly better than before treatment of (67.20 ±7.20)% and (66.98 ±6.82)% (P < 0.05), the observation group after treatment FEV1 value was higher than the control group (P < 0.05). The quality of life scores of the observation group and the control group after treatment were (36.44 ±5.14) and (42.30 ±5.00) points respectively, the scores of the observation group were lower than those of the control group (P < 0.05).Conclusion Aminophylline can promote the recovery of clinical symptoms in the treatment of patients with non acute stage recurrent bronchitis, it can improve lung function and the therapeutic effect, it also can improve the overall quality of life.
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