目的 探讨双相门冬胰岛素30与地特胰岛素对口服降糖药失败的2型糖尿病（T2DM）患者的疗效及低血糖发生的影响。方法 选择2014年1月-2017年1月南阳市宛城区第一人民医院收治的86例口服降糖药失败的T2DM患者，根据入院先后顺序，分为A组及B组，A组患者每日早晚腹部皮下注射1次双相门冬胰岛素30，B组每日睡前（21：00-22：00）腹部皮下注射一次地特胰岛素，两组均治疗24周。观察两组治疗前后的空腹血糖（FBG）、糖化血红蛋白（HbAlc）及体质量，对比两组治疗期间的血糖达标时间、低血糖事件发生率。结果 与治疗前相比，两组治疗后的FBG、HbAlc均明显下降，差异有统计学意义（P<0.05）；两组治疗前后组间的FBG及HbAlc对比差异无统计学意义。两组治疗前后及组间的体质量指数对比均无统计学意义；两组的血糖达标时间对比差异无统计学意义，但A组的低血糖发生率明显高于B组，差异有统计学意义（P<0.05）。结论 口服降糖药失败后的T2DM患者应用双相门冬胰岛素30或地特胰岛素，疗效相当，但地特胰岛素低血糖发生率较低，应用较为安全。

Objective To investigate the efficacy and hypoglycemia occurs influence of BIAsp30 and insulin detemir on T2DM who were oral hypoglycemic drugs failed.Methods 86 cases with T2DM who were Oral hypoglycemic drugs failed in our hospital from Jan. 2014 to Jan. 2017 were chosen and divided into A group (BIAsp30 group) and B group (insulin detemir). The fasting blood glucose, glycosylated hemoglobin and body mass of two groups before and after treatment were observed, the blood glucose standard time, low blood glucose incident rate of two groups in treatment were compared.Results Compared with before treatment, the FBG, HbAlc of two groups after treatment were all decreased (P < 0.05). The FBG and HbAlc of two groups before and after treatment had no significant difference. The body mass of two groups before and after treatment had no significant difference. The blood glucose standard time of two groups had no significant, while the hypoglycemia occurs of A groups were obvious higher than B group (P < 0.05).Conclusion T2DM who were oral hypoglycemic drugs failed were given BIAsp30 and insulin detemir had therapeutic equivalence, while the insulin detemir had lower hypoglycemia occurs, which was safety in clinical.