隐丹参酮是从中药丹参里提取的一种天然活性成分，具有多种药理作用，不仅能预防和治疗缺血性疾病、冠状动脉疾病和阿尔茨海默氏症，还具有良好的抗肿瘤活性。它通过抑制肿瘤细胞增殖、诱导肿瘤细胞凋亡、抑制肿瘤转移和侵袭、抗新血管生成及调控活性氧水平等途径发挥抗肿瘤作用。对近年来研究的隐丹参酮的抗肿瘤活性和作用机制进行综述。

Cryptotanshinone is a natural compound isolated from the plant Salvia miltiorrhiza Bunge. It has many pharmacological effects, including prevention and treatment of acute ischemic stroke, coronary artery disease, Alzheimer's disease and anti-cancer. Recent studies have been shown that cryptotanshinone also could inhibit proliferation and induce apoptosis of cancer cells, inhibit migration, invasion and angiogenesis of tumor cells, and regulating the levels of reactive oxygen species to exert antitumor pharmacological activity. This study will review the antitumor pharmacological activity and the mechanism of cryptotanshinone.

黑龙江省科学基金资助项目（LC2015036）；黑龙江省大学生创新创业训练计划项目（201710223001）