[关键词]
[摘要]
参附注射液作为传统方剂参附汤的现代用药形式,在临床发挥了重要作用。前期研究发现其对心血管系统疾病,包括心律失常,心力衰竭,失血性、感染性休克,再灌注损伤方面的保护作用。随着研究不断深入,还发现其对缺血脑损伤、神经源性肺水肿、慢阻肺、腹膜透析参与肾功能、化疗及麻醉术后不良反应的改善作用,均有确切疗效。作用机制主要涉及改善血流动力学,抗炎、抗凝血、抗凋亡,改善代谢,增强免疫等多方面。就参附注射液的临床应用及药理作用机制做一综述,以期进一步挖掘其潜在疗效并更好地应用于临床。
[Key word]
[Abstract]
As the main application forms of Shenfu Detection, ShenFu injection has played an important role in the clinical practice. In previous studies, we found that it plays a protective role in cardiovascular diseases, including arrhythmia, heart failure, hemorrhagic, septic shock and reperfusion injury. With the deepening of our research, we also found that it can improve the effects of ischemic brain injury, neurogenic pulmonary edema, chronic obstructive pulmonary disease and peritoneal dialysis on renal function, chemotherapy and adverse reactions after anesthesia. The mechanism of action mainly involves the improvement of hemodynamics, anti-inflammatory, anticoagulant, anti-apoptosis, improvement of metabolism, and enhancement of immune and other aspects. In this paper, the pharmacological action and specific mechanism of Shenfu injection are reviewed in order to further explore its potential efficacy and apply it to clinical practice.
[中图分类号]
[基金项目]
国家自然科学基金资助项目(81473591,81573867)