目的 探讨对新生儿缺氧缺血性脑病应用单唾液酸四己糖神经节苷脂钠注射液联合高压氧治疗的临床效果，分析对患儿血清相关因子的影响。方法 选取2012年1月—2017年5月安康市中心医院诊治的缺氧缺血性脑病患儿96例，根据随机数字表法分成2组，分别是对照组和研究组，每组各48例，将常规治疗联合高压氧治疗应用于对照组，将单唾液酸四己糖神经节苷脂钠注射液联合高压氧治疗应用于研究组，共治疗3个疗程。对比两组患儿的治疗总有效率、意识反射恢复时间、可吸吮恢复时间、意识恢复时间、肌张力恢复时间，血清可溶性细胞间黏附分子-1（sICAM-1）、生长激素（GH）和胰岛素样生长因子-1（IGF-1）等水平。结果 治疗后对照组患儿的肌张力恢复时间、意识反射恢复时间、可吸吮恢复时间、意识恢复时间显著高于研究组（P<0.05）；对照组患儿治疗后的总有效率为81.2%，显著低于研究组患儿治疗后的总有效率93.7%（P<0.05）。治疗后，两组血清IGF-1、GH水平均显著高于治疗前（P<0.05），血清sICAM-1水平显著低于治疗前（P<0.05）；且研究组治疗后血清IGF-1、GH水平均显著高于对照组（P<0.05），血清sICAM-1水平显著低于对照组（P<0.05）。结论 对新生儿缺氧缺血性脑病患者应用单唾液酸四己糖神经节苷脂钠注射液联合高压氧治疗的临床效果佳，可以有效降低患儿血清sICAM-1水平，有效提高患儿血清IGF-1水平和GH水平，值得推广。

Objective To explore the effect of the combined hyperbaric oxygenation of monosialic acid tetrahexylic acid on the treatment of neonatal hypoxic ischemic encephalopathy and the effect of the analysis on the serum correlation factors. Methods Collected in January 2012 to May 2017 in Ankang Center Hospital 96 cases of children with hypoxic ischemic encephalopathy as the research object, using digital grouping method is divided into research group and control group, with one sialic acid team with four hexose ganglioside sodium injection combined hyperbaric oxygen treatment, children with the control group using conventional treatment combined hyperbaric oxygen treatment, compared two groups of children with muscle tone recovery time, consciousness recovery time, recovery time reflected, can suck the recovery time, total effective rate of treatment, and serum IGF-1, GH and sICAM-1 level indicator. Results The time of recovery time, consciousness recovery time, conscious reflex recovery time and the recovery time of the recovery time were shorter than those in the control group (P<0.05). The total effective rate was 81.2% after treatment of the children in the control group. The total effective rate was 93.7% after the treatment of the children in the study group, and the difference between the two groups was statistically significant (P<0.05). Of the two groups after treatment in children with serum IGF-1, GH levels before treatment were increased obviously (P<0.05), was significantly lower the serum levels of sICAM-1 compared with the control group (P<0.05). Conclusions Single sialic acid four hexose ganglioside sodium injection combined hyperbaric oxygen treatment of neonatal hypoxic ischemic encephalopathy clinical curative effect is good, can effectively increase with serum IGF-1, GH level and lower serum level of sICAM-1 and is worth further explore clinical research and application.