[关键词]
[摘要]
急性骨髓性白血病是成人常见的白血病类型,发病率随年龄的增长而升高,病情进展迅速,严重威胁人类健康。恩西地平(Enasidenib,Idhifa®)是第一个异柠檬酸脱氢酶2抑制剂,能有效治疗该酶变异导致的急性骨髓性白血病,也是美国食品药品管理局批准的唯一一个针对这一患者群体的肿瘤代谢疗法新药。对恩西地平的作用机制、药效学、药动学、药物相互作用、临床评价和安全性等进行综述,旨在为临床应用提供有益的参考。
[Key word]
[Abstract]
Acute myelocytic leukemia (AML) is a common type of leukemia massively afflicting the adults. The incidence of the disease increases with age with aggressive development, which pose a severe threaten to human health. Enasidenib (Idhifa®) is the first inhibitor against isocitrate dehydrogenase2 (IDH2), which is globally approved by FDA for the potent treatment of adults with refractory IDH2-mutated AML as well as represents a sole therapy through regulating cancer metabolism for the patients with AML. The mechanism, pharmacodynamics, pharmacokinetics, drug interaction, clinical evaluation, and safety of Enasidenib were reviewed to provide the beneficial reference for the clinic application in the near future.
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