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[摘要]
目的 对比枸橼酸咖啡因与氨茶碱治疗呼吸暂停(AOP)早产儿的临床效果。方法 2016年1月-2017年6月濮阳市油田总医院儿科监护室收治的AOP早产儿190例,按照入院先后顺序随机数表分组,分为观察组与对照组各95例,观察组应用枸橼酸咖啡因治疗,对照组应用氨茶碱治疗。记录与观察两组新生儿箱内吸氧时间与总氧疗时间、AOP消失时间与住院时间及动脉导管未闭(PDA)、支气管肺发育不良(BPD)、早产儿视网膜病(ROP)等并发症发生情况和不良反应。结果 观察组的箱内吸氧时间与总氧疗时间都显著少于对照组,差异有统计学意义(P<0.05)。观察组的AOP消失时间与住院时间分别为(20.44±3.19)h和(38.29±3.11)d,都显著少于对照组的(26.55±4.51)h和(45.33±5.98)d,差异有统计学意义(P<0.05)。两组治疗期间的动脉导管未闭、支气管肺发育不良、视网膜病变等并发症发生情况对比无显著差异。观察组治疗期间的心动过速、高血糖、喂养不耐受的发生率分别为1.1%、2.1%和3.2%,都显著低于对照组的10.5%、9.5%和12.6%,差异有统计学意义(P<0.05)。结论 相对于氨茶碱,枸橼酸咖啡因治疗早产儿AOP能促进患儿的康复,缩短氧疗时间,减少不良反应的发生,且不会增加严重并发症的发生。
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[Abstract]
Objective To compare the clinical effects of aminophylline and caffeine citrate in the treatment of preterm infants with apnea (AOP). Methods From January 2016 -June 2017, 190 cases of preterm infants with AOP admitted in our hospital pediatric care unit were randomly divided into observation group and control group with 95 cases in each group accorded the grouped tables. The observation group was used caffeine citrate treatment, and the control group was used the aminophylline treatment, recorded the prognosis of the two groups. Results The oxygen inhalation time and total oxygen therapy time in the observation group were significantly less than that of the control group (P<0.05). The disappearance time of AOP and the time of hospitalization in the observation group were (20.44±3.19) h and (38.29±3.11) d, respectively, which were significantly less than (26.55±4.51) h and (45.33±5.98) d in the control group (P<0.05). There were no significant difference in the incidence of complications such as patent ductus arteriosus, bronchopulmonary dysplasia and retinopathy during the treatment of the two groups. The incidence of tachycardia, hyperglycemia and feeding intolerance in the observation group were 1.1%, 2.1% and 3.2%, respectively, which were significantly lower than those in the control group 10.5%, 9.5% and 12.6% (P<0.05). Conclusion Compares with aminophylline, caffeine citrate in the treatment of AOP in premature infants can promote the rehabilitation of children, shorten the time of oxygen therapy, reduce the occurrence of adverse reactions, and will not increase the incidence of serious complications.
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