目的 评价小儿肺热咳喘口服液联合阿奇霉素治疗支原体肺炎的有效性和安全性。方法 中国知网（CNKI）、万方数据库（WF）、维普数据库（VIP）、中国生物医学全文数据库（CBM）、PubMed、EMbase和Cochrane Library等数据库，纳入随机对照试验（RCT），提取有效数据进行Meta-分析。结果 共纳入12个RCT，1 234病例，试验组619例，对照组615例。Meta结果显示，小儿肺热咳喘口服液联合阿奇霉素在总有效率[RR=1.18，95% CI（1.13，1.23），P<0.000 01]，退热时间[MD=-0.85，95% CI（-1.19，-0.51），P<0.000 01]、咳嗽消失时间[MD=-2.54，95% CI（-3.38，-1.69），P<0.000 01]、肺部啰音消失时间[MD=-1.53，95% CI（-2.24，-0.81），P<0.000 1]、咳痰消失时间[MD=-1.63，95% CI（-1.96，-1.30），P<0.000 01]及减少住院天数方面均优于单用阿奇霉素，差异均有统计学意义；两组不良反应发生率（RR=0.70，95% CI（0.26，1.87），P=0.48），差异无统计学意义。结论 小儿肺热咳喘口服液联合阿奇霉素治疗儿童支原体肺炎的疗效优于单用阿奇霉素，且联合应用并未增加不良反应发生率。

Objective To evaluate the efficacy and safety of Xiao'er Feire Kechuan Oral Liquid combined with azithromycin in the treatment of pediatric mycoplasma mycoplasma pneumonia. Methods The databases of PubMed, EMbase, Cochrane Library, CKNI, WF, VIP, and CBM were systematically searched to collect the randomized controlled trials (RCTs), the valid data from which were entered Meta-analysis. Results A total of 12 RCTs were brought in, including 1234 cases, of which 619 cases were in the treatment group and 615 were in the control group. Meta-analysis showed that clinical efficacy of treatment group of Xiao'er Feire Kechuan Oral Liquid combined with azithromycin was superior than those in single azithromycin group at the total effective rate of[RR=1.18, 95% CI (1.13, 1.23), P<0.000 01], fever subsidence time of[MD=-0.85, 95% CI (-1.19, -0.51), P<0.000 01], cough disappearance time of[MD=-2.54, 95% CI (-3.38, -1.69), P<0.000 01], lung rales disappearance time of[MD=-1.53, 95% CI (-2.24, -0.81), P<0.000 01], expectoration disappearance time[MD=-1.63, 95% CI (-1.96, -1.30), P<0.000 01], and reduction of hospital stay. The differences between groups were statistically significant. There was no statistical difference in the adverse effects[RR=0.70, 95% CI (0.26, 1.87), P=0.48] between two groups. Conclusion Xiao'er Feire Kechuan Oral Liquid combined with azithromycin might have a better clinical efficacy on the pediatric mycoplasma mycoplasma pneumonia than using azithromycin singly, and the combined application of medicine did not increase the incidence of adverse reactions