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[摘要]
目的 通过成本-效果分析,评价儿童清咽解热口服液治疗小儿急性咽炎(肺胃实热证)的经济学优劣。方法 共纳入急性咽炎(肺胃实热证)患儿219例,以2:1:1的比例随机分为试验组、阳性药对照组、安慰剂对照组,在以抗生素为基础治疗的条件下,分别服用儿童清咽解热口服液、蒲地蓝消炎口服液(阳性对照药)、安慰剂,疗程为5 d。选取咽痛疗效、疾病疗效和中医症候疗效作为评价指标,进行成本-效果分析。结果 在咽痛疗效方面,试验组每多获得1个单位的愈显率,比安慰剂组仅需多花费0.62元,比阳性对照组少花费0.54元;在疾病疗效方面,试验组每多获得1个单位的愈显率,比安慰剂组多花费0.57元,比阳性对照组少花费0.54元;在中医证候方面,试验组每多获得1个单位的愈显率,比安慰剂组多花费0.58元,比阳性对照组少花费0.54元。结论 儿童清咽解热口服液联合抗生素治疗小儿急性咽炎(肺胃实热证),在咽痛症状疗效、疾病疗效和中医症候疗效方面,较蒲地蓝消炎口服液及单独使用抗生素有较优的经济性,与蒲地蓝消炎口服液经济性相当,具有良好的临床应用前景。
[Key word]
[Abstract]
Objective To evaluate cost-effectiveness of Qingyan Jiere Oral Liquid for the treatment of acute pharyngitis (lung-stomach excess-heat syndrome). Methods 219 patients were assigned to this study, and were randomly divided into treatment group, positive control group, and placebo control group in rate of 2:1:1. All patients took Azithromycin Granules as basic treatment, then took Qingyan Jiere Oral Liquid, Pudilan Xiaoyan Oral Liquid, or placebo, respectively. Treatment course lasted for 5 d. The curative effect of throat pain, efficacy of disease, and the traditional Chinese medicine (TCM) symptoms were observed by cost-effectiveness analysis. Results For analgesic efficacy, to get one more unit of markedly effective rate, patients in the treatment group need pay 0.62 yuan more than placebo group, and save 0.54 yuan when comparing with positive control group. For disease curative efficacy, to get one more percentage point of markedly effective rate, patients in the treatment group need pay extra 0.57 yuan than placebo group, and save 0.54 yuan than positive control group. For TCM syndrome efficacy, to get one more percentage point of markedly effective rate, patients in the treatment group need pay extra 0.58 yuan than placebo group, and save 0.54 yuan than positive control group. Conclusion Qingyan Jiere Oral Liquid, with cost-effectiveness advantage on relieving sore throat, curing disease and improving TCM symptoms, is a good choice for treating acute pharyngitis (lung-stomach excess-heat syndrome).
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