目的 建立用于测定注射用益气复脉（冻干）（YQFM）中总有机酸含量的电位滴定方法。方法 注射用益气复脉（冻干）用水溶解后，经001*1阳离子交换树脂将盐还原为酸，以琥珀酸为对照品，用电位滴定法测定益气复脉中总有机酸的含量。结果 以琥珀酸计，YQFM中总有机酸滴定精密度RSD 0.42%，稳定性RSD 0.84%，重复性RSD 1.88%，平均加样回收率（n=9）为100.15%，RSD 1.68%。结论 本实验所建立的电位滴定方法简便易行，可操作性强，适用于YQFM中总有机酸的含量测定。

Objective To establish a potentiometric titration analytical method for the determination of the total organic acids in Yiqi Fumai Lyophilized Injection (YQFM). Methods With butanedioic acid as reference, the total organic acids in purified YQFM were detected by potentiometric titration. Result The precision, stability, and repeatability of the method were very good with RSD 0.42%, 0.84%, and 1.88%, respectively. The average recovery (n=9) of the method was 100.15% with RSD 1.68%. Conclusion The method is feasible and reproducible, which is suitable for the determination of the total organic acids in YQFM.