目的 考查不同材质及不同孔径的超滤膜对5种麦冬皂苷类成分的影响。方法 以麦冬皂苷C、麦冬皂苷D、麦冬皂苷D'、麦冬皂苷Ra、龙血苷F为考察指标，利用HPLC-UV法测定其超滤前后变化，考察不同材质及孔径的超滤膜对5种麦冬皂苷收率的影响以及各超滤阶段对麦冬皂苷类成分截留率的变化情况。结果 不同材质及不同孔径的超滤膜处理下，麦冬皂苷类成分的收率不同；聚醚砜材质超滤膜对各超滤阶段的麦冬皂苷类成分截留率变化趋势与纤维素材质是一致的。结论 采用100 kDa的聚醚砜超滤膜，可以使麦冬皂苷类成分的收率达到最高，用50%乙醇进行等体积透析，会对麦冬皂苷的收率有较大的改善。

Objective To investigate the effect of the ultrafiltration membrane with different materials and different sizes on five saponins of Ophipogon japonicas. Methods Using Ophipogonin C, ophipogonin D, ophipogonin D', ophipogonin Ra, and dracaenoside F as index, determine the change of the content before and after the ultrafiltration membrane to measure the effect on the yield of ophiopogonins by HPLC-UV, observe the influence of different materials and pore sizes of ultrafiltration membrane on yields of 5 kinds of saponins. Results The yield of ophiopogonins from Radix Ophiopogonis was different under different material and pore size. The variation trend of the retention rate of ophiopogonins in the ultrafiltration stage was consistent with that of cellulose. Conclusion Using 100kDapolyethersulfone ultrafiltration membrane will have the highest yield of ophiopogonins. Using 50% ethanol for equal volume dialysis can greatly improve the yield of Ophiopogonjaponicus saponin.